Differential Effects of Haloperidol and Clozapine on Attention

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1984 Jan 1

PMID 6438688

Citations 5

Authors

M Cheal

Affiliations

Soon will be listed here.

Abstract

Haloperidol (0, 0.1, 0.3, or 1.0 mg/kg), the typical butyrophenone neuroleptic, decreased investigation of novel objects by gerbils following systemic injections. When given prior to apomorphine (1 or 3 mg/kg), haloperidol blocked apomorphine-induced disruption of selective attention in a dose-dependent manner. Thus, haloperidol acts like pimozide in this paradigm. In contrast, clozapine (0, 0.03, 0.1, 0.3, 1.0, or 3.0 mg/kg), the atypical dibenzodiazepine neuroleptic, increased frequency of investigation both soon after injection and 24h later, suggesting interference with maintenance of attention. When given with apomorphine (1.0 mg/kg), clozapine did not block apomorphine effects on selective attention. The results are related to differential effects of these neuroleptics on other behaviors and to their individual pharmacological profiles.

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References

Cheal M, Klestzick J, Domesick V . Attention and habituation: odor preferences, long-term memory, and multiple sensory cues of novel stimuli. J Comp Physiol Psychol. 1982; 96(1):47-60. DOI: 10.1037/h0077854. View

CORRODI H, Farnebo L, Fuxe K, Hamberger B, Ungerstedt U . ET495 and brain catecholamine mechanisms: evidence for stimulation of dopamine receptors. Eur J Pharmacol. 1972; 20(2):195-204. DOI: 10.1016/0014-2999(72)90149-5. View

EVERETT G, Borcherding J . L-dopa: effect on concentrations of dopamine, norepinephrine, and serotonin in brains of mice. Science. 1970; 168(3933):849-50. DOI: 10.1126/science.168.3933.849. View

Spring B, Nuechterlein K, Sugarman J, Matthysse S . The "new look" in studies of schizophrenic attention and information processing. Schizophr Bull. 1977; 3(3):470-82. DOI: 10.1093/schbul/3.3.470. View

Cheal M . Scopolamine disrupts maintenance of attention rather than memory processes. Behav Neural Biol. 1981; 33(2):163-87. DOI: 10.1016/s0163-1047(81)91612-5. View

Costall B, Naylor R . Actions of dopaminergic agonists on motor function. Adv Neurol. 1975; 9:285-97. View

LJUNGBERG T, Ungerstedt U . Classification of neuroleptic drugs according to their ability to inhibit apomorphine-induced locomotion and gnawing: evidence for two different mechanisms of action. Psychopharmacology (Berl). 1978; 56(3):239-47. DOI: 10.1007/BF00432845. View

Cheal M . L-Dopa and piribedil alter different components of attentional behavior dependent on dose. Psychopharmacology (Berl). 1983; 80(4):345-50. DOI: 10.1007/BF00432118. View

Svensson T, Usdin T . Feedback inhibition of brain noradrenaline neurons by tricyclic antidepressants: alpha-receptor mediation. Science. 1978; 202(4372):1089-91. DOI: 10.1126/science.213833. View

10.

Ungerstedt U . Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl. 1971; 367:1-48. DOI: 10.1111/j.1365-201x.1971.tb10998.x. View

11.

Janssen P, NIEMEGEERS C, SCHELLEKENS K, Lenaerts F . Is it possible to predict the clinical effects of neuroleptic drugs (major tranquillizers) from animal data? IV. An improved experimental design for measuring the inhibitory effects of neuroleptic drugs on amphetamine-or apomorphine-induced.... Arzneimittelforschung. 1967; 17(7):841-54. View

12.

Stawarz R, Hill H, Robinson S, Setler P, DINGELL J, Sulser F . On the significance of the increase in homovanillic acid (HVA) caused by antipsychotic drugs in corpus striatum and limbic forebrain. Psychopharmacologia. 1975; 43(2):125-30. DOI: 10.1007/BF00421014. View

13.

Blumberg J, Vetulani J, Stawarz R, Sulser F . The noradrenergic cyclic AMP generating system in the limbic forebrain: pharmacological characterization in vitro and possible role of limbic noradrenergic mechanisms in the mode of action of antipsychotics. Eur J Pharmacol. 1976; 37(2):357-66. DOI: 10.1016/0014-2999(76)90043-1. View

14.

Cheal M, Johnson M, Ellingboe J, Skupny A . Perseveration of attention to conspecific odors and novel objects in castrated gerbils. Physiol Behav. 1984; 33(4):563-70. DOI: 10.1016/0031-9384(84)90372-x. View

15.

NIEMEGEERS C, Janssen P . A systematic study of the pharmacological activities of dopamine antagonists. Life Sci. 1979; 24(24):2201-16. DOI: 10.1016/0024-3205(79)90096-1. View

16.

ANDEN N, Strombom U, Svensson T . Locomotor stimulation by L-dopa: relative importance of noradrenaline receptor activation. Psychopharmacology (Berl). 1977; 54(3):243-8. DOI: 10.1007/BF00426571. View

17.

Rebec G, Bashore T, Zimmerman K, Alloway K . Neostriatal and mesolimbic neurons: dose-dependent effects of clozapine. Neuropharmacology. 1980; 19(3):281-8. DOI: 10.1016/0028-3908(80)90151-3. View

18.

Tye N, Horsman L, Wright F, Large B, Pullar I . Two dopamine receptors: supportive evidence with the rat rotational model. Eur J Pharmacol. 1977; 45(1):87-90. DOI: 10.1016/0014-2999(77)90063-2. View

19.

Iversen S, Koob G . Behavioral implications of dopaminergic neurons in the mesolimbic system. Adv Biochem Psychopharmacol. 1977; 16:209-14. View

20.

Cheal M . Attention and habituation: catecholamine interactions and sex differences. Pharmacol Biochem Behav. 1982; 16(3):377-85. DOI: 10.1016/0091-3057(82)90438-5. View