Cholinergic Learning Deficits in the Marmoset Produced by Scopolamine and ICV Hemicholinium

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1984 Jan 1

PMID 6436862

Citations 11

Authors

R M Ridley

N G Barratt

H F Baker

Affiliations

Soon will be listed here.

Abstract

Common marmosets (Callithrix jacchus) were trained to perform daily position discrimination learning tasks in a Wisconsin General Test Apparatus. Acetylcholine receptor blockade with scopolamine was found to impair position learning. Testing on the day after scopolamine treatment suggested that a task learnt under scopolamine was not encoded into long term memory. Acetylcholine depletion achieved by the intraventricular injection of hemicholinium 4 h before testing resulted in a profound impairment of position discrimination learning. It is suggested that central acetylcholine depletion in primates may provide a useful model of senile dementia.

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References

Perry E, Perry R, Blessed G, Tomlinson B . Necropsy evidence of central cholinergic deficits in senile dementia. Lancet. 1977; 1(8004):189. DOI: 10.1016/s0140-6736(77)91780-9. View

Miles R, MEYER D . Learning sets in marmosets. J Comp Physiol Psychol. 1956; 49(3):219-22. DOI: 10.1037/h0045088. View

MEYER D . Food deprivation and discrimination reversal learning by monkeys. J Exp Psychol. 1951; 41(1):10-6. DOI: 10.1037/h0061488. View

Drachman D . Memory and cognitive function in man: does the cholinergic system have a specific role?. Neurology. 1977; 27(8):783-90. DOI: 10.1212/wnl.27.8.783. View

Davies P, Verth A . Regional distribution of muscarinic acetylcholine receptor in normal and Alzheimer's-type dementia brains. Brain Res. 1977; 138(2):385-92. DOI: 10.1016/0006-8993(77)90758-2. View

OVERTON D . STATE-DEPENDENT OR "DISSOCIATED" LEARNING PRODUCED WITH PENTOBARBITAL. J Comp Physiol Psychol. 1964; 57:3-12. DOI: 10.1037/h0048023. View

COTTERMAN T, MEYER D, Wickens D . Discrimination reversal learning in marmosets. J Comp Physiol Psychol. 1956; 49(6):539-41. DOI: 10.1037/h0048341. View

Yamamura H, Snyder S . High affinity transport of choline into synaptosomes of rat brain. J Neurochem. 1973; 21(6):1355-74. DOI: 10.1111/j.1471-4159.1973.tb06022.x. View

Safer D, Allen R . The central effects of scopolamine in man. Biol Psychiatry. 1971; 3(4):347-55. View

10.

Bartus R, JOHNSON H . Short-term memory in the rhesus monkey: disruption from the anti-cholinergic scopolamine. Pharmacol Biochem Behav. 1976; 5(1):39-46. DOI: 10.1016/0091-3057(76)90286-0. View

11.

Evans H . Scopolamine effects on visual discrimination: modifications related to stimulus control. J Pharmacol Exp Ther. 1975; 195(1):105-13. View

12.

Glick S, Jarvik M . Amphetamine, scopolamine and chlorpromazine interactions on delayed matching performance in monkeys. Psychopharmacologia. 1969; 16(2):147-55. DOI: 10.1007/BF00403617. View

13.

RUSSELL R, Macri J . Some behavioral effects of suppressing choline transport by cerebroventricular injection of hemicholinium-3. Pharmacol Biochem Behav. 1978; 8(4):399-403. DOI: 10.1016/0091-3057(78)90076-x. View

14.

DAVIS R . Problem-solving behavior of monkeys as a function of work variables. J Comp Physiol Psychol. 1956; 49(5):499-506. DOI: 10.1037/h0046849. View

15.

Mewaldt S, Ghoneim M . The effects and interactions of scopolamine, physostigmine and methamphetamine on human memory. Pharmacol Biochem Behav. 1979; 10(2):205-10. DOI: 10.1016/0091-3057(79)90088-1. View

16.

Perry E, Tomlinson B, Blessed G, Bergmann K, Gibson P, Perry R . Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J. 1978; 2(6150):1457-9. PMC: 1608703. DOI: 10.1136/bmj.2.6150.1457. View

17.

Freeman J, Macri J, Choi R, JENDEN D . Studies on the behavioral and biochemical effects of hemicholinium in vivo. J Pharmacol Exp Ther. 1979; 210(1):91-7. View

18.

Miles R . Discrimination in the squirrel monkey as a function of deprivation and problem difficulty. J Exp Psychol. 1959; 57(1):15-9. DOI: 10.1037/h0049280. View

19.

Crow T . An analysis of the learning deficit following hyoscine administration to man. Br J Pharmacol. 1973; 49(2):322-7. PMC: 1776392. DOI: 10.1111/j.1476-5381.1973.tb08379.x. View

20.

Bohdanecky Z, Jarvik M, Carley J . Differential impairment of delayed matching in monkeys by scopolamine and scopolamine methylbromide. Psychopharmacologia. 1967; 11(4):293-9. DOI: 10.1007/BF00404606. View