Calcium Supplementation and Postmenopausal Bone Loss

Overview

Journal Br Med J (Clin Res Ed)

Specialty General Medicine

Date 1984 Oct 27

PMID 6435793

Citations 28

Authors

L Nilas

C Christiansen

P RODBRO

Affiliations

Soon will be listed here.

Abstract

A series of 103 early postmenopausal women completed a questionnaire about their dietary calcium intake and were then divided into three groups: those with an intake below 550 mg/day, those with an intake between 550 and 1150 mg/day, and those with an intake above 1150 mg/day. Thereafter they were given a daily supplement of 500 mg calcium for two years and had their bone mineral content measured every three months. Any changes found were taken as an estimate of bone calcium balance. All three groups showed a similar fall in bone mineral content over the two years, indicating that a calcium intake of 1000-2000 g daily is ineffective in preventing bone loss in the early menopause.

Citing Articles

Effect of Denosumab on Bone Density in Postmenopausal Osteoporosis: A Comparison with and without Calcium Supplementation in Patients on Standard Diets in Korea.

Jeong C, Kim J, Lee J, Lim Y, Lim D, Baek K J Clin Med. 2023; 12(21).

PMID: 37959369 PMC: 10649665. DOI: 10.3390/jcm12216904.

Calcium revisited: part II calcium supplements and their effects.

Lamy O, Burckhardt P Bonekey Rep. 2014; 3:579.

PMID: 25328675 PMC: 4189255. DOI: 10.1038/bonekey.2014.74.

Dietary calcium intake, vitamin D status, and bone health in postmenopausal women in rural Pakistan.

Lowe N, Ellahi B, Bano Q, Bangash S, Mitra S, Zaman M J Health Popul Nutr. 2011; 29(5):465-70.

PMID: 22106752 PMC: 3225108. DOI: 10.3329/jhpn.v29i5.8900.

Osteoporosis: prevention and management strategies.

Evers S, Myers A Can Fam Physician. 2011; 33:151-5.

PMID: 21267348 PMC: 2218284.

Prevention of osteoporosis.

Hogan D Can Fam Physician. 2011; 33:701-4.

PMID: 21263861 PMC: 2218358.

References

Christensen M . A sensitive radioimmunoassay of parathyroid hormone in human serum using a specific extraction procedure. Scand J Clin Lab Invest. 1976; 36(4):313-22. DOI: 10.1080/00365517609055266. View

Marshall D, Horsman A, Nordin B . The prevention and management of post-menopausal osteoporosis. Acta Obstet Gynecol Scand Suppl. 1977; 65:49-56. DOI: 10.3109/00016347709156341. View

Heaney R, Recker R, SAVILLE P . Calcium balance and calcium requirements in middle-aged women. Am J Clin Nutr. 1977; 30(10):1603-11. DOI: 10.1093/ajcn/30.10.1603. View

Horsman A, Gallagher J, Simpson M, Nordin B . Prospective trial of oestrogen and calcium in postmenopausal women. Br Med J. 1977; 2(6090):789-92. PMC: 1631969. DOI: 10.1136/bmj.2.6090.789. View

Recker R, SAVILLE P, Heaney R . Effect of estrogens and calcium carbonate on bone loss in postmenopausal women. Ann Intern Med. 1977; 87(6):649-55. DOI: 10.7326/0003-4819-87-6-649. View

Christiansen C, RODBRO P . Long-term reproducibility of bone mineral content measurements. Scand J Clin Lab Invest. 1977; 37(4):321-3. DOI: 10.3109/00365517709092636. View

Heaney R, Recker R, SAVILLE P . Menopausal changes in calcium balance performance. J Lab Clin Med. 1978; 92(6):953-63. View

NACHTIGALL L, Nachtigall R, Nachtigall R, Beckman E . Estrogen replacement therapy I: a 10-year prospective study in the relationship to osteoporosis. Obstet Gynecol. 1979; 53(3):277-81. View

Weiss N, Ure C, Ballard J, Williams A, Daling J . Decreased risk of fractures of the hip and lower forearm with postmenopausal use of estrogen. N Engl J Med. 1980; 303(21):1195-8. DOI: 10.1056/NEJM198011203032102. View

10.

Christiansen C, Christensen M, McNair P, Hagen C, STOCKLUND K, TRANSBOL I . Prevention of early postmenopausal bone loss: controlled 2-year study in 315 normal females. Eur J Clin Invest. 1980; 10(4):273-9. DOI: 10.1111/j.1365-2362.1980.tb00033.x. View

11.

Jensen J . Trochanteric fractures. An epidemiological, clinical and biomechanical study. Acta Orthop Scand Suppl. 1981; 188:1-100. DOI: 10.3109/ort.1981.52.suppl-188.01. View

12.

Christiansen C, Christensen M, RODBRO P, Hagen C, TRANSBOL I . Effect of 1,25-dihydroxy-vitamin D3 in itself or combined with hormone treatment in preventing postmenopausal osteoporosis. Eur J Clin Invest. 1981; 11(4):305-9. DOI: 10.1111/j.1365-2362.1981.tb02121.x. View

13.

Riggs B, Seeman E, Hodgson S, Taves D, OFallon W . Effect of the fluoride/calcium regimen on vertebral fracture occurrence in postmenopausal osteoporosis. Comparison with conventional therapy. N Engl J Med. 1982; 306(8):446-50. DOI: 10.1056/NEJM198202253060802. View

14.

Jensen G, Christiansen C, BOESEN J, Hegedus V, TRANSBOL I . Epidemiology of postmenopausal spinal and long bone fractures. A unifying approach to postmenopausal osteoporosis. Clin Orthop Relat Res. 1982; (166):75-81. View

15.

Christensen M, Hagen C, Christiansen C, TRANSBOL I . Dose-response evaluation of cyclic estrogen/gestagen in postmenopausal women: placebo-controlled trial of its gynecologic and metabolic actions. Am J Obstet Gynecol. 1982; 144(8):873-9. DOI: 10.1016/0002-9378(82)90176-4. View