The Effects of Auranofin and Parenteral Gold in the Treatment of Rheumatoid Arthritis: an X-ray Analysis

Overview

Journal Clin Rheumatol

Publisher Springer

Specialty Rheumatology

Date 1984 Mar 1

PMID 6432419

Citations 7

Authors

A Larsen

J Horton

C Howland

Affiliations

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Abstract

X-rays from patients in comparative studies of auranofin and parenteral gold were obtained before and during treatment, and analysed using a modification of the method of Larsen. One hundred and nineteen auranofin-treated and 113 parenteral gold-treated patients contributed data, which were analysed for changes from 0-6 months, 0-12 months and from 0-6 and 12 months. Progression of erosive processes and of joint grade occurred with both treatments, but the proportion of patients with progression in the first six months was greater with auranofin treatment. However, there was evidence that both treatments produced slowing of the erosive process during the second six months of treatment.

Citing Articles

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Contribution of patient related differences to multidrug resistance in rheumatoid arthritis.

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Prospective six year follow up of patients withdrawn from a randomised study comparing parenteral gold salt and methotrexate.

Sander O, Herborn G, Bock E, Rau R Ann Rheum Dis. 1999; 58(5):281-7.

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Disease-modifying antirheumatic drugs. Potential effects in older patients.

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Worldwide clinical experience with auranofin.

Morris R, Cole D, Horton J, HEUER M, Pietrusko R Clin Rheumatol. 1984; 3 Suppl 1:105-11.

PMID: 6432408 DOI: 10.1007/BF03342628.

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