Methysergide Decreases Prolactin Release After FK 33-824 [Tyr-D-Ala-Gly-MePhe-Met(o)-ol], a Potent Analogue of Methionine Enkephalin. A Study in Man

Overview

Journal Psychopharmacology (Berl)

Specialty Pharmacology

Date 1984 Jan 1

PMID 6431476

Citations 1

Authors

G Jungkunz

N Nedopil

E Ruther

Affiliations

Soon will be listed here.

Abstract

This study investigated the mechanisms which may underly the prolactin (PRL) stimulating effects of FK 33-824, a potent enkephalin analogue. FK 33-824 (1 mg) was infused in healthy volunteers before and after pretreatment with 3 mg methysergide, a serotonin receptor blocker. All subjects showed a release of PRL after FK 33-824, which was significantly diminished after pretreatment with methysergide.

Citing Articles

Effects of methysergide, bromocriptine and naloxone on prolactin, growth hormone and TSH release induced by D-Met2,Pro5-enkephalinamide in man.

Foldes J, Varadi A, Gara A, Banos C, Vargha P, Torok K Psychopharmacology (Berl). 1986; 88(3):331-5.

PMID: 3083453 DOI: 10.1007/BF00180834.

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