Increase in Cytosolic Ca2+ Concentration During T-butyl Hydroperoxide Metabolism by Isolated Hepatocytes Involves NADPH Oxidation and Mobilization of Intracellular Ca2+ Stores

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1984 Mar 12

PMID 6423407

Citations 13

Authors

G Bellomo

H Thor

S Orrenius

Affiliations

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Abstract

Activation of phosphorylase a in hepatocytes incubated with t-butyl hydroperoxide indicates that hydroperoxide metabolism is associated with an increase in cytosolic free Ca2+ concentration which appears to be mediated by NADPH oxidation and to involve mobilization of intracellular Ca2+ stores.

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