Demonstration of Autoreceptors on Dopamine Neurons in Different Brain Regions of Rats Treated with Gammabutyrolactone

Overview

Journal J Neural Transm

Specialties Neurology
Physiology

Date 1983 Jan 1

PMID 6420514

Citations 9

Authors

N E ANDEN

M Grabowska-Anden

B Liljenberg

Affiliations

Soon will be listed here.

Abstract

Following interruption of the nerve impulse flow in the dopamine neurons by treatment with gammabutyrolactone, the selective dopamine autoreceptor agonist B-HT 920 reduced the DOPA accumulation after DOPA decarboxylase inhibition and the 3,4-dihydroxyphenylacetic acid concentration in the corpus striatum, the nucleus accumbens, the olfactory tubercle, the limbic cortex and the rostral part of the cerebral cortex of rats. The effects were completely inhibited by the dopamine receptor antagonist haloperidol, indicating that they were caused by stimulation of dopamine autoreceptors. In the caudal part of the cerebral cortex and the cerebellum, B-HT 920 somewhat reduced the concentration of dihydroxyphenylacetic acid via a haloperidol-sensitive mechanism, suggesting that there are a few dopamine neurons with autoreceptors in these regions. No evidence was obtained for the presence of autoreceptors on the dopamine neurons in the hypothalamus. The gammabutyrolactone-induced elevation of the dopamine concentration was not reduced by B-HT 920 in any region, suggesting that this effect of gammabutyrolactone was caused by decreased release rather than increased synthesis of dopamine under our experimental circumstances.

Citing Articles

Current Review of the Function and Regulation of Tuberoinfundibular Dopamine Neurons.

Qi-Lytle X, Sayers S, Wagner E Int J Mol Sci. 2024; 25(1).

PMID: 38203281 PMC: 10778701. DOI: 10.3390/ijms25010110.

Dopamine-receptor agonists: mechanisms underlying autoreceptor selectivity. I. Review of the evidence.

Clark D, Hjorth S, Carlsson A J Neural Transm. 1985; 62(1-2):1-52.

PMID: 3894582 DOI: 10.1007/BF01260414.

Central dopaminergic properties of HW-165 and its enantiomers; trans-octahydrobenzo(f)quinoline congeners of 3-PPP.

Hjorth S, Svensson K, Carlsson A, Wikstrom H, Andersson B Naunyn Schmiedebergs Arch Pharmacol. 1986; 333(3):205-18.

PMID: 3762735 DOI: 10.1007/BF00512931.

Does treatment with haloperidol for 3 weeks produce depolarization block in midbrain dopamine neurons of unanaesthetized rats?.

ANDEN N, Grenhoff J, Svensson T Psychopharmacology (Berl). 1988; 96(4):558-60.

PMID: 3149782 DOI: 10.1007/BF02180041.

NSD 1034: an amino acid decarboxylase inhibitor with a stimulatory action on dopamine synthesis not mediated by classical dopamine receptors.

Nissbrandt H, Engberg G, Wikstrom H, Magnusson T, Carlsson A Naunyn Schmiedebergs Arch Pharmacol. 1988; 338(2):148-61.

PMID: 3141816 DOI: 10.1007/BF00174863.

References

Gudelsky G, Moore E . Differential drug effects on dopamine concentrations and rates of turnover in the median eminence, olfactory tubercle and corpus striatum. J Neural Transm. 1976; 38(2):95-105. DOI: 10.1007/BF01262968. View

ANDEN N, Nilsson H, Ros E, Thornstrom U . Effects of B-HT 920 and B-HT 933 on dopamine and noradrenaline autoreceptors in the rat brain. Acta Pharmacol Toxicol (Copenh). 1983; 52(1):51-6. DOI: 10.1111/j.1600-0773.1983.tb01075.x. View

ANDEN N, Magnusson T, Stock G . Effects of drugs influencing monoamine mechanisms on the increase in brain dopamine produced by axotomy or treatment with gammahydroxybutyric acid. Naunyn Schmiedebergs Arch Pharmacol. 1973; 278(4):363-72. DOI: 10.1007/BF00501480. View

Moore K, Wuerthele S . Regulation of nigrostriatal and tuberoinfundibular-hypophyseal dopaminergic neurons. Prog Neurobiol. 1979; 13(3):325-59. DOI: 10.1016/0301-0082(79)90019-4. View

ANDEN N, Thornstrom U . Selective stimulation of dopamine and noradrenaline autoreceptors by B-HT 920 and B-HT 933, respectively. Naunyn Schmiedebergs Arch Pharmacol. 1982; 321(2):100-4. DOI: 10.1007/BF00518475. View

Felice L, Felice J, Kissinger P . Determination of catecholamines in rat brain parts by reverse-phase ion-pair liquid chromatography. J Neurochem. 1978; 31(6):1461-5. DOI: 10.1111/j.1471-4159.1978.tb06573.x. View

ANDEN N, Grabowska-Anden M, Liljenberg B . On the presence of autoreceptors on dopamine neurons in different brain regions. J Neural Transm. 1983; 57(3):129-37. DOI: 10.1007/BF01245113. View

Walters J, Roth R . Dopaminergic neurons: drug-induced antagonism of the increase in tyrosine hydroxylase activity produced by cessation of impulse flow. J Pharmacol Exp Ther. 1974; 191(1):82-91. View

Umezu K, Moore K . Effects of drugs on regional brain concentrations of dopamine and dihydroxyphenylacetic acid. J Pharmacol Exp Ther. 1979; 208(1):49-56. View

10.

Handforth A, Sourkes T . Inhibition by dopamine agonists of dopamine accumulation following gamma-hydroxybutyrate treatment. Eur J Pharmacol. 1975; 34(2):311-9. DOI: 10.1016/0014-2999(75)90257-5. View

11.

Demarest K, Moore K . Comparison of dopamine synthesis regulation in the terminals of nigrostriatal, mesolimbic, tuberoinfundibular and tuberohypophyseal neurons. J Neural Transm. 1979; 46(4):263-77. DOI: 10.1007/BF01259333. View

12.

Fuxe K . CELLULAR LOCALIZATION OF MONOAMINES IN THE MEDIAN EMINENCE AND IN THE INFUNDIBULAR STEM OF SOME MAMMALS. Acta Physiol Scand. 1963; 58:383-4. DOI: 10.1111/j.1748-1716.1963.tb02662.x. View

13.

ANDEN N, Grabowska-Anden M, Lindgren S, Thornstrom U . Synthesis rate of dopamine: difference between corpus striatum and limbic system as a possible explanation of variations in reactions to drugs. Naunyn Schmiedebergs Arch Pharmacol. 1983; 323(3):193-8. DOI: 10.1007/BF00497662. View

14.

Bannon M, Michaud R, Roth R . Mesocortical dopamine neurons. Lack of autoreceptors modulating dopamine synthesis. Mol Pharmacol. 1981; 19(2):270-5. View

15.

Bannon M, Reinhard Jr J, Bunney E, Roth R . Unique response to antipsychotic drugs is due to absence of terminal autoreceptors in mesocortical dopamine neurones. Nature. 1982; 296(5856):444-6. DOI: 10.1038/296444a0. View

16.

Fuxe K, HILLARP N . UPTAKE OF L-DOPA AND NORADRENALINE BY CENTRAL CATECHOLAMINE NEURONS. Life Sci (1962). 1964; 3:1403-6. DOI: 10.1016/0024-3205(64)90081-5. View

17.

Walters J, Roth R . Dopaminergic neurons: an in vivo system for measuring drug interactions with presynaptic receptors. Naunyn Schmiedebergs Arch Pharmacol. 1976; 296(1):5-14. DOI: 10.1007/BF00498834. View

18.

Carlsson A, Davis J, KEHR W, Lindqvist M, Atack C . Simultaneous measurement of tyrosine and tryptophan hydroxylase activities in brain in vivo using an inhibitor of the aromatic amino acid decarboxylase. Naunyn Schmiedebergs Arch Pharmacol. 1972; 275(2):153-68. DOI: 10.1007/BF00508904. View

19.

Nauta W, Smith G, Faull R, Domesick V . Efferent connections and nigral afferents of the nucleus accumbens septi in the rat. Neuroscience. 1978; 3(4-5):385-401. DOI: 10.1016/0306-4522(78)90041-6. View