Defective Activation by Glucose of Hepatic Glycogen Synthesis in the Obese Hyperglycaemic Mouse

Overview

Journal Biochem J

Specialty Biochemistry

Date 1983 Nov 15

PMID 6419733

Citations 1

Authors

S A Smith

M A Cawthorne

A L Levy

D L Simson

Affiliations

Soon will be listed here.

Abstract

The administration of an oral glucose load to 24 h-starved lean (+/?) male C57BL/6 mice produced a rapid, 7-fold increase in the rate of hepatic glycogen synthesis and a sustained activation of glycogen synthase. In contrast, glucose produced only a small (4.5-fold), short-lived increase in hepatic glycogen synthesis in genetically obese (ob/ob) mice and no activation of glycogen synthase.

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van de Werve G, Jeanrenaud B Diabetologia. 1987; 30(3):169-74.

PMID: 3034711 DOI: 10.1007/BF00274223.

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