The Effect of Prophylaxis for Thrombosis on Heterotopic Ossification Following Total Hip Joint Replacement

Overview

Journal Arch Orthop Trauma Surg (1978)

Specialty Orthopedics

Date 1983 Jan 1

PMID 6419710

Citations 5

Authors

R Eyb

K Knahr

Affiliations

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Abstract

The effect of prophylaxis for thrombosis on heterotopic ossification was investigated using 216 total hip joint endoprostheses implanted between 1976 and 1978. During this period a random comparative study of low dose heparin and oxyphenbutazone/acetylsalycilic acid was carried out. The rate of ossification in the 216 hip joints was 17.6%, and was about average for the values specified in literature on this subject. Heterotopic ossification occurred in 30.1% of the 103 hip joints treated with heparin, whilst the rate of ossification in the 113 hip joints treated with oxyphenbutazone/acetylsalycilic acid was only 6.2%. This represents a statistically significant difference in disfavour of prophylaxis with heparin.

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Effects of acetylsalicylic acid on heterotopic bone resorption and formation in rats.

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