Prolonged Small-intestinal Transit Time in Cystic Fibrosis

Overview

Journal Br Med J (Clin Res Ed)

Specialty General Medicine

Date 1983 Oct 8

PMID 6412927

Citations 28

Authors

A Bali

D E Stableforth

P Asquith

Affiliations

Soon will be listed here.

Abstract

A lactulose hydrogen breath test was performed on 10 patients with cystic fibrosis and 15 control subjects matched for age and sex. All normal subjects had a fasting breath hydrogen concentration of less than 20 ppm. In contrast, seven of the patients with cystic fibrosis had high concentrations (25-170 ppm), which fell to 20 ppm or below on prolonged fasting (14-23 hours). Two patients showed no rise in breath hydrogen concentrations after lactulose, and in one patient the breath hydrogen concentration rose at 15 minutes, suggesting bacterial colonisation of the small bowel. Seven of the patients had prolonged small-bowel transit times (160-390 minutes) compared with those in the control group (50-150 minutes).

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References

Bond Jr J, Levitt M . Use of pulmonary hydrogen (H 2 ) measurements to quantitate carbohydrate absorption. Study of partially gastrectomized patients. J Clin Invest. 1972; 51(5):1219-25. PMC: 292253. DOI: 10.1172/JCI106916. View

Bond Jr J, Levitt M, Prentiss R . Investigation of small bowel transit time in man utilizing pulmonary hydrogen (H2) measurements. J Lab Clin Med. 1975; 85(4):546-55. View

Gilat T, Ben Hur H, Terdiman R, Peled Y . Alterations of the colonic flora and their effect on the hydrogen breath test. Gut. 1978; 19(7):602-5. PMC: 1412075. DOI: 10.1136/gut.19.7.602. View

Park R, Grand R . Gastrointestinal manifestations of cystic fibrosis: a review. Gastroenterology. 1981; 81(6):1143-61. View

Gillon J, Tadesse K, Logan R, Holt S, Sircus W . Breath hydrogen in pneumatosis cystoides intestinalis. Gut. 1979; 20(11):1008-11. PMC: 1412673. DOI: 10.1136/gut.20.11.1008. View

Rhodes J, Middleton P, Jewell D . The lactulose hydrogen breath test as a diagnostic test for small-bowel bacterial overgrowth. Scand J Gastroenterol. 1979; 14(3):333-6. DOI: 10.3109/00365527909179892. View

McCollum J, Muller D, HARRIES J . Test meal for assessing intraluminal phase of absorption in childhood. Arch Dis Child. 1977; 52(11):887-9. PMC: 1544826. DOI: 10.1136/adc.52.11.887. View

Matsehe J, Go V, DiMagno E . Meconium ileus equivalent complicating cystic fibrosis in postneonatal children and young adults. Report of 12 cases. Gastroenterology. 1977; 72(4 Pt 1):732-6. View

Bond J, Levitt M . Use of breath hydrogen (H2) in the study of carbohydrate absorption. Am J Dig Dis. 1977; 22(4):379-82. DOI: 10.1007/BF01072197. View

10.

Metz G, Gassull M, Drasar B, Jenkins D, Blendis L . Breath-hydrogen test for small-intestinal bacterial colonisation. Lancet. 1976; 1(7961):668-9. DOI: 10.1016/s0140-6736(76)92779-3. View

11.

Wood R, Herman C, Johnson K, di SantAgnese P . Pneumatosis coli in cystic fibrosis: clinical, radiological, and pathological features. Am J Dis Child. 1975; 129(2):246-8. DOI: 10.1001/archpedi.1975.02120390072016. View

12.

Tadesse K, Eastwood M . Metabolism of dietary fibre components in man assessed by breath hydrogen and methane. Br J Nutr. 1978; 40(2):393-6. DOI: 10.1079/bjn19780136. View

13.

Weber A, Roy C, Morin C, LASALLE R . Malabsorption of bile acids in children with cystic fibrosis. N Engl J Med. 1973; 289(19):1001-5. DOI: 10.1056/NEJM197311082891903. View

14.

Corbett C, Thomas S, Read N, Hobson N, Bergman I, HOLDSWORTH C . Electrochemical detector for breath hydrogen determination: measurement of small bowel transit time in normal subjects and patients with the irritable bowel syndrome. Gut. 1981; 22(10):836-40. PMC: 1419428. DOI: 10.1136/gut.22.10.836. View

15.

Levitt M . Production and excretion of hydrogen gas in man. N Engl J Med. 1969; 281(3):122-7. DOI: 10.1056/NEJM196907172810303. View

16.

Boyle B, Long W, Balistreri W, Widzer S, Huang N . Effect of cimetidine and pancreatic enzymes on serum and fecal bile acids and fat absorption in cystic fibrosis. Gastroenterology. 1980; 78(5 Pt 1):950-3. View

17.

Metz G, Jenkins D, Newman A, Blends L . Breath hydrogen in hyposucrasia. Lancet. 1976; 1(7951):119-20. DOI: 10.1016/s0140-6736(76)93157-3. View

18.

REILLY R, Kirsner J . The blind loop syndrome. Gastroenterology. 1959; 37:491-4. View