Involvement of Calcium Ions in the Activation of Ornithine Decarboxylase by Isoprenaline Evaluated 'in Situ' in the Perfused Rat Heart

Overview

Journal Biochem J

Specialty Biochemistry

Date 1983 Apr 15

PMID 6409100

Citations 1

Authors

C Guarnieri

F Flamigni

C Muscari

C M Caldarera

Affiliations

Soon will be listed here.

Abstract

Ornithine decarboxylase activity evaluated during the perfusion of isolated rat hearts by a method 'in situ' was rapidly increased when the hearts were infused with isoprenaline (isoproterenol). Omission of Ca2+ from the perfusion medium or the administration of verapamil to the perfused hearts decreased the isoprenaline-stimulated ornithine decarboxylase activity, whereas a marked stimulatory effect was registered when the hearts were perfused with the Ca2+ ionophore A23187.

Citing Articles

Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy.

Tsikas D, Redfors B Int J Mol Sci. 2022; 23(9).

PMID: 35563125 PMC: 9103764. DOI: 10.3390/ijms23094734.

References

Reed P, LARDY H . A23187: a divalent cation ionophore. J Biol Chem. 1972; 247(21):6970-7. View

Langer G, Serena S, Nudd L . Localization of contractile-dependent Ca: comparison of Mn and verapamil in cardiac and skeletal muslce. Am J Physiol. 1975; 229(4):1003-7. DOI: 10.1152/ajplegacy.1975.229.4.1003. View

Warnica J, Antony P, Gibson K, Harris P . The effect of isoprenaline and propranolol on rat myocardial ornithine decarboxylase. Cardiovasc Res. 1975; 9(6):793-6. DOI: 10.1093/cvr/9.6.793. View

DAmore P, Shepro D . Calcium flux and ornithine decarboxylase activity in cultured endothelial cells. Life Sci. 1978; 22(7):571-6. DOI: 10.1016/0024-3205(78)90335-1. View

Corti A, Casti A, Mezzetti G, Reali N, Orlandini G, Caldarera C . Modifications of major aspects of myocardial ribonucleic acid metabolism as a response to noradrenaline. Action of the hormone on cytoplasmic processing of ribonucleic acid after reserpine treatment. Biochem J. 1977; 168(3):341-5. PMC: 1183778. DOI: 10.1042/bj1680341. View

Guarnieri C, Ferrari R, VISIOLI O, Caldarera C, NAYLER W . Effect of alpha-tocopherol on hypoxic-perfused and reoxygenated rabbit heart muscle. J Mol Cell Cardiol. 1978; 10(10):893-906. DOI: 10.1016/0022-2828(78)90336-x. View

Fuller R, Hemrick S . Studies of noradrenergic influence on cardiac ornithine decarboxylase in rats. J Mol Cell Cardiol. 1978; 10(11):1031-6. DOI: 10.1016/0022-2828(78)90399-1. View

Costa M, Nye J . Calcium, asparagine and cAMP are required for ornithine decarboxylase activation in intact Chinese hamster ovary cells. Biochem Biophys Res Commun. 1978; 85(3):1156-64. DOI: 10.1016/0006-291x(78)90663-0. View

Lau C, Slotkin T . Regulation of rat heart ornithine decarboxylase: change in affinity for ornithine evoked by neuronal, hormonal, and ontogenetic stimuli. Mol Pharmacol. 1979; 16(2):504-12. View

10.

Veldhuis J, Harrison T, Hammond J . Beta-2-Adrenergic stimulation of ornithine decarboxylase activity in porcine granulosa cells in vitro. Biochim Biophys Acta. 1980; 627(2):123-30. DOI: 10.1016/0304-4165(80)90314-1. View

11.

Gibbs J, Hsu C, Terasaki W, Brooker G . Calcium and microtubule dependence for increased ornithine decarboxylase activity stimulated by beta-adrenergic agonists, dibutyryl cyclic AMP, or serum in a rat astrocytoma cell line. Proc Natl Acad Sci U S A. 1980; 77(2):995-9. PMC: 348410. DOI: 10.1073/pnas.77.2.995. View

12.

CANELLAKIS Z, Theoharides T, Bondy P, Triarhos E . The role of calcium in the induction of ornithine decarboxylase in rat HTC cells. Life Sci. 1981; 29(7):707-10. DOI: 10.1016/0024-3205(81)90023-0. View

13.

Veldhuis J, Hammond J . Role of calcium in the modulation of ornithine decarboxylase activity in isolated pig granulosa cells in vitro. Biochem J. 1981; 196(3):795-801. PMC: 1163100. DOI: 10.1042/bj1960795. View

14.

Copeland J, Larson D, Roeske W, Russell D, Womble J . beta 2-Adrenoceptors regulate induction of myocardial ornithine decarboxylase in mice in vivo. Br J Pharmacol. 1982; 75(3):479-83. PMC: 2071574. DOI: 10.1111/j.1476-5381.1982.tb09164.x. View

15.

Otani S, Kuramoto A, Matsui I, Morisawa S . Induction of ornithine decarboxylase in guinea pig lymphocytes by the divalent cation ionophore A 23187. Effect of dibutyryladenosine 3',5'-monophosphate. Eur J Biochem. 1982; 125(1):35-40. DOI: 10.1111/j.1432-1033.1982.tb06647.x. View