A Role for Taurine in the Maintenance of Homeostasis in the Central Nervous System During Hyperexcitation?

Overview

Journal Neurosci Lett

Specialty Neurology

Date 1984 Dec 21

PMID 6395048

Citations 12

Authors

A Lehmann

H Hagberg

A Hamberger

Affiliations

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Abstract

Employing the brain dialysis technique, we demonstrate that the aspartate congener N-methyl-D,L-aspartic acid (NMA) stimulates the release of endogenous taurine in vivo in a Ca2+-dependent manner. Furthermore, exogenous taurine (1-10 mM) inhibits the NMA-induced Ca2+ influx into intracellular compartments. This suggests that the extracellular taurine concentration may control Ca2+ movement and thereby provide a homeostatic mechanism in situations of excessive excitation.

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