Effect of Insulin on Glucose Metabolism in Adipocytes from Virgin and Late-pregnant Rats

Overview

Journal Biochem J

Specialty Biochemistry

Date 1984 Dec 1

PMID 6393953

Citations 2

Authors

A Leturque

M Guerre-Millo

M LAVAU

J Girard

Affiliations

Soon will be listed here.

Abstract

Under basal conditions (zero insulin), paraovarian adipocytes from 19-day-pregnant rats exhibited the same rates of [U-14C]glucose conversion into CO2 and total lipids as did those from age-matched virgin rats. The dose-response curves for insulin stimulation of glucose metabolism were similar in both groups: maximal response (+100% over basal values) and high sensitivity (half-maximal effect at 0.05 nM-insulin). The present results suggest that the insulin resistance in vivo that occurs during late pregnancy may involve circulating factors lost in vitro.

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