The Inhibition of Lymphocyte Mitogenesis by Asparaginase: a Still Unexplained Phenomenon

Overview

Journal Experientia

Specialty Science

Date 1984 Nov 15

PMID 6389170

Citations 2

Authors

D Kafkewitz

A Bendich

Affiliations

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Citing Articles

L-asparaginase of Thermus thermophilus: purification, properties and identification of essential amino acids for its catalytic activity.

Pritsa A, Kyriakidis D Mol Cell Biochem. 2001; 216(1-2):93-101.

PMID: 11216870 DOI: 10.1023/a:1011066129771.

Antiproliferative activity of L-asparaginase of Tetrahymena pyriformis on human breast cancer cell lines.

Kyriakidis D, Tsirka S, Tsavdaridis I, Iliadis S, Kortsaris A Mol Cell Biochem. 1990; 96(2):137-42.

PMID: 2125695 DOI: 10.1007/BF00420905.

References

Kahn J, Fidler I . L-asparaginase and alteration of lymphocyte surface. Inhibition of the rat mixed leukocyte interaction. J Med. 1973; 4(4):248-56. View

Bendich A, Kafkewitz D, Abuchowski A, DAVIS F . Inhibition of blastogenesis by native and polyethylene glycol-modified asparaginases from Escherichia coli and Vibrio succinogenes. Immunol Commun. 1983; 12(3):273-84. DOI: 10.3109/08820138309050749. View

Distasio J, Niederman R, Kafkewitz D, Goodman D . Purification and characterization of L-asparaginase with anti-lymphoma activity from Vibrio succinogenes. J Biol Chem. 1976; 251(22):6929-33. View

Fidler I, Montgomery P, Ferguson E . L-asparaginase and lymphocyte blastogenesis. Lancet. 1971; 2(7733):1091-2. DOI: 10.1016/s0140-6736(71)90407-7. View

Abuchowski A, van Es T, Palczuk N, DAVIS F . Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J Biol Chem. 1977; 252(11):3578-81. View

Weiner M, WAITHE W, Hirschhorn K . L-asparaginase and blastogenesis. Lancet. 1969; 2(7623):748. DOI: 10.1016/s0140-6736(69)90464-4. View

WAITHE W, Dauphinais C, HATHAWAY P, Hirschhorn K . Protein synthesis in stimulated lymphocytes. II. Amino acid requirements. Cell Immunol. 1975; 17(2):323-34. DOI: 10.1016/s0008-8749(75)80036-0. View

DARTNALL J . L-asparaginase and blastogenesis. Lancet. 1969; 2(7634):1357-8. DOI: 10.1016/s0140-6736(69)90888-5. View

BERENBAUM M, COPE W, Jeffery W . Differential asparaginase sensitivity of T-cell and B-cell responses. Clin Exp Immunol. 1973; 15(4):565-72. PMC: 1553962. View

10.

Horowitz B, Madras B, Meister A, Old L, Boyes E, STOCKERT E . Asparagine synthetase activity of mouse leukemias. Science. 1968; 160(3827):533-5. DOI: 10.1126/science.160.3827.533. View

11.

Simberkoff M, Thomas L . Reversal by L-glutamine of the inhibition of lymphocyte mitosis caused by E. coli asparaginase. Proc Soc Exp Biol Med. 1970; 133(2):642-4. DOI: 10.3181/00379727-133-34535. View

12.

Burgio G, Astaldi Jr A, Vaccaro R, Gasparoni M . [Immunosuppresive properties of L-asparaginase. Effects on lymphocyte mixed culture (in vitro) and on immunoglobulin levels of the serum]. Monatsschr Kinderheilkd (1902). 1971; 119(7):439-42. View

13.

Benezra D, Pitaro R, Birkenfeld V, HOCHMAN A . Reversal of the immunosuppressive effect of L-asparaginase by L-glutamine. Nat New Biol. 1972; 236(64):80-2. DOI: 10.1038/newbio236080a0. View

14.

Fidler I, Montgomery P, Cesarini J . Modification of surface topography of lymphocytes by L-asparaginase. Cancer Res. 1973; 33(12):3176-80. View

15.

Baechtel F, GREGG D, Prager M . The influence of glutamine, its decomposition products, and glutaminase on the transformation of human and mouse lymphocytes. Biochim Biophys Acta. 1976; 421(1):33-43. DOI: 10.1016/0304-4165(76)90167-7. View

16.

SORU E, Teodorescu M, Zaharia O, SZABADOS J, Rudescu K . L-Asparaginase from the BCG strain of Mycobacterium bovis. I. Purification and in vitro immunosuppressive properties. Can J Biochem. 1972; 50(11):1149-57. DOI: 10.1139/o72-157. View

17.

ASTALDI G . [On the so-called antiblastic activity of L-asparaginase]. Boll Ist Sieroter Milan. 1971; 50(4):278-90. View

18.

Dubrow R, PIZER L, Brody J . Serine-glycine requirement of phytohemagglutinin-stimulated lymphocytes. J Natl Cancer Inst. 1973; 51(1):307-11. DOI: 10.1093/jnci/51.1.307. View

19.

Ohno R, Hersh E . Immunosuppressive effects of L-asparaginase. Cancer Res. 1970; 30(6):1605-11. View

20.

KIDD J . Regression of transplanted lymphomas induced in vivo by means of normal guinea pig serum. I. Course of transplanted cancers of various kinds in mice and rats given guinea pig serum, horse serum, or rabbit serum. J Exp Med. 1953; 98(6):565-82. PMC: 2136344. DOI: 10.1084/jem.98.6.565. View