Anti-LPS Factor in the Horseshoe Crab, Tachypleus Tridentatus. Its Hemolytic Activity on the Red Blood Cell Sensitized with Lipopolysaccharide

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 1984 Oct 15

PMID 6386521

Citations 11

Authors

K Ohashi

M Niwa

T Nakamura

T Morita

S Iwanaga

Affiliations

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Abstract

Anti-LPS factor, which inhibits the endotoxin mediated coagulation system in the horseshoe crab, Tachypleus tridentatus, was found to lyse red blood cells sensitized with gram-negative bacterial LPS, but not to lyse unsensitized cells. This hemolysis occurred even at 0 degree C and was completed within 1 min. The binding of anti-LPS factor to LPS must be essential for the hemolysis, because free LPS inhibited the hemolytic action of anti-LPS factor.

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