Immunoreactive Gonadotropin-releasing Hormone Level in Maternal Circulation Throughout Pregnancy
Overview
Authors
Affiliations
Immunoreactive gonadotropin-releasing hormone was quantitated in maternal blood. Circulating levels of gonadotropin-releasing hormone were found to be significantly higher during pregnancy than in nonpregnant cycling women. The highest concentrations of gonadotropin-releasing hormone immunoreactivity were observed in the first half of pregnancy with values at 20 to 42 weeks being significantly lower. A correlation with placental human chorionic gonadotropin-releasing hormone concentrations and maternal circulating gonadotropin-releasing hormone levels was noted. Four pregnancies that resulted in premature labor and/or delivery had very low circulating maternal gonadotropin-releasing hormone concentrations, possibly reflecting placental dysfunction in these cases.
Maternal programming: Application of a developmental psychopathology perspective.
Glynn L, Howland M, Fox M Dev Psychopathol. 2018; 30(3):905-919.
PMID: 30068423 PMC: 6274636. DOI: 10.1017/S0954579418000524.
Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations.
Teo A, Garg S, Haris Shaikh L, Zhou J, Karet Frankl F, Gurnell M N Engl J Med. 2015; 373(15):1429-36.
PMID: 26397949 PMC: 4612399. DOI: 10.1056/NEJMoa1504869.
Chen Y, Holzman C, Chung H, Senagore P, Talge N, Siler-Khodr T Psychoneuroendocrinology. 2009; 35(6):820-32.
PMID: 20006448 PMC: 2875356. DOI: 10.1016/j.psyneuen.2009.11.007.
Gohar J, Mazor M, Leiberman J Arch Gynecol Obstet. 1996; 259(1):1-6.
PMID: 8933922 DOI: 10.1007/BF02505301.
New aspects of placental endocrinology.
Petraglia F, Calza L, Garuti G, Giardino L, De Ramundo B, Angioni S J Endocrinol Invest. 1990; 13(4):353-71.
PMID: 1973427 DOI: 10.1007/BF03349579.