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Pulmonary Cell Response in Mice Following Intranasal Instillation with Cryptococcus Neoformans

Overview
Journal Mycopathologia
Specialties Microbiology
Pharmacology
Date 1984 Jun 30
PMID 6382016
Citations 2
Authors
D M Anderson
M A Dykstra
Affiliations
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Abstract

Cryptococcus neoformans was instilled intranasally into mice which were sacrificed to determine the fate of instilled cryptococci and the pulmonary cellular response. During the first 12 h, instilled cryptococci decreased significantly in numbers and did not disseminate to extrapulmonary sites. There was a transient increase in neutrophils which may have been due to an influx of bacteria which accompanied the process of intranasal instillation.

Citing Articles

In vivo interaction between alveolar macrophages and Cryptococcus neoformans.

Nessa K, Gross N, Jarstrand C, Johansson A, Camner P Mycopathologia. 1997; 139(1):1-7.

PMID: 9511230 DOI: 10.1023/a:1006843202124.

Persistence of infection in mice inoculated intranasally with Cryptococcus neoformans.

Anderson D, Sagha H Mycopathologia. 1988; 104(3):163-9.

PMID: 3070384 DOI: 10.1007/BF00437432.

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