Clinical and Subclinical Organ-specific Autoimmune Manifestations in Type 1 (insulin-dependent) Diabetic Patients and Their First-degree Relatives

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1984 Jun 1

PMID 6381190

Citations 36

Authors

C Betterle

F Zanette

B Pedini

F Presotto

L B Rapp

C M Monciotti

F Rigon

Affiliations

Soon will be listed here.

Abstract

Studying 239 Type 1 (insulin-dependent) diabetic patients and 144 of their first-degree relatives, we found a significant prevalence of autoimmune manifestations in both groups, compared with sex- and age-matched control subjects (p less than 0.001). In particular, in diabetic patients we found a high frequency of autoimmune thyroid disease and idiopathic Addison's disease and also a significant prevalence of thyroid (p less than 0.001), parietal cell (p less than 0.05) and adrenal antibodies (p less than 0.05). In the relatives a high frequency of thyroid disease, thyroid, parietal cell and adrenal antibodies and a significant prevalence of islet cell antibodies (p less than 0.05) were detected. In both groups functional glandular tests and gastric biopsies performed on the basis of autoantibody positivity revealed 13 examples of subclinical hypothyroidism, two cases of reduced adrenocortical reserve and five of atrophic gastritis. Autoantibody screening in diabetic patients and their relatives permitted the early diagnosis of the underlying endocrine disorders.

Citing Articles

Parietal Cell Antibodies in Type 1 Diabetes Mellitus and Its Implications for Iron Deficiency: A Tertiary Centre Experience from North India.

Bhat K, Verma S, Bhatia E, Bhatia V, Sudhanshu S Indian J Endocrinol Metab. 2024; 28(5):536-541.

PMID: 39676778 PMC: 11642518. DOI: 10.4103/ijem.ijem_176_24.

Coexistence of Autoimmune Disorders and Type 1 Diabetes Mellitus in Children: An Observation from Western Part of India.

Sharma B, Nehara H, Saran S, Bhavi V, Singh A, Mathur S Indian J Endocrinol Metab. 2019; 23(1):22-26.

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Intravitreal pro-inflammatory cytokines in non-obese diabetic mice: Modelling signs of diabetic retinopathy.

Mugisho O, Rupenthal I, Squirrell D, Bould S, Danesh-Meyer H, Zhang J PLoS One. 2018; 13(8):e0202156.

PMID: 30133488 PMC: 6105000. DOI: 10.1371/journal.pone.0202156.

Thyroid profile and autoantibodies in Type 1 diabetes subjects: A perspective from Eastern India.

Sanyal D, Majumder A, Chaudhuri S, Chatterjee S Indian J Endocrinol Metab. 2017; 21(1):45-50.

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Type 1 Diabetic Populations Have an Increased Prevalence of Parietal Cell Antibody: A Systematic Review and Meta-Analysis.

Pan X, Gu J, Shan Z Medicine (Baltimore). 2015; 94(38):e1440.

PMID: 26402802 PMC: 4635742. DOI: 10.1097/MD.0000000000001440.

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