Spontaneous Hypertension and Hypertensive Renal Disease in the Fawn-hooded Rat

Overview

Journal Br J Exp Pathol

Specialty Pathology

Date 1984 Apr 1

PMID 6370289

Citations 22

Authors

M H Kuijpers

E Gruys

Affiliations

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Abstract

The fawn-hooded (FH) rat, a strain characterized by a platelet storage-pool disease, developed focal and segmental glomerulosclerosis at the age of 2-3 months (males) and approximately 6 months (females). Male animals died spontaneously at 11-13 months, and females at 15 months of age, both with overt malignant nephrosclerosis. During the first half year of life focal glomeruli showed depositions of IgG, IgA, IgM, C3 and fibrinogen in a segmental pattern and mainly in mesangial areas. Mesangial IgG and IgA were already demonstrable at the age of 5 weeks. On electron microscopy no electron-dense deposits suggestive of immune complexes were found. Mean arterial blood pressure in 5.5-month-old male FH rats was increased compared with that of matched Wistar rats. One-year-old FH rats had severe hypertension. The presumed relationship between the hypertension, the renal lesions and the blood platelet defect is discussed.

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References

DUFFY J, Cinque T, Grishman E, Churg J . Intraglomerular fibrin, platelet aggregation, and subendothelial deposits in lipoid nephrosis. J Clin Invest. 1970; 49(2):251-8. PMC: 322467. DOI: 10.1172/JCI106234. View

Coccheri S, Fiorentini P . Platelet adhesiveness and aggregation in hypertensive patients. Acta Med Scand Suppl. 1971; 525:273-5. DOI: 10.1111/j.0954-6820.1972.tb05842.x. View

Tschopp T, ZUCKER M . Hereditary defect in platelet function in rats. Blood. 1972; 40(2):217-26. View

Kincaid-Smith P . Coagulation and renal disease. Kidney Int. 1972; 2(4):183-90. DOI: 10.1038/ki.1972.93. View

Habib R . Editorial: Focal glomerular sclerosis. Kidney Int. 1973; 4(6):355-61. DOI: 10.1038/ki.1973.131. View

Aarden L, de Groot E, FELTKAMP T . Immunology of DNA. III. Crithidia luciliae, a simple substrate for the determination of anti-dsDNA with the immunofluorescence technique. Ann N Y Acad Sci. 1975; 254:505-15. DOI: 10.1111/j.1749-6632.1975.tb29197.x. View

Bolton W, Benton F, Maclay J, STURGILL B . Spontaneous glomerular sclerosis in aging Sprague-Dawley rats. I. Lesions associated with mesangial IgM deposits. Am J Pathol. 1976; 85(2):277-302. PMC: 2032571. View

Dixon R, Rosse W . Mechanism of complement-mediated activation of human blood platelets in vitro: comparison of normal and paroxysmal nocturnal hemoglobinuria platelets. J Clin Invest. 1977; 59(2):360-8. PMC: 333367. DOI: 10.1172/JCI108648. View

Compston J, Horton L, Laker M, Ayers A, Woodhead J, BULL H . Bone disease after jejuno-ileal bypass for obesity. Lancet. 1978; 2(8079):1-4. DOI: 10.1016/s0140-6736(78)91318-1. View

10.

Kreisberg J, Karnovsky M . Focal glomerular sclerosis in the fawn-hooded rat. Am J Pathol. 1978; 92(3):637-52. PMC: 2018261. View

11.

Parbtani A, Cameron J . Platelet and plasma serotonin concentration in glomerulonephritis I. Thromb Res. 1979; 15(1-2):109-25. DOI: 10.1016/0049-3848(79)90057-4. View

12.

Michael A, Keane W, Raij L, Vernier R, MAUER S . The glomerular mesangium. Kidney Int. 1980; 17(2):141-54. DOI: 10.1038/ki.1980.18. View

13.

Michels L, Davidman M, Keane W . The effects of chronic mesangial immune injury on glomerular function. J Lab Clin Med. 1980; 96(3):396-407. View

14.

Barcelli U, RADEMACHER R, Ooi Y, Ooi B . Modification of glomerular immune complex deposition in mice by activation of the reticuloendothelial system. J Clin Invest. 1981; 67(1):20-7. PMC: 371567. DOI: 10.1172/JCI110013. View

15.

Olivetti G, Kithier K, Giacomelli F, Wiener J . Glomerular permeability to endogenous proteins in the rat: effects of acute hypertension. Lab Invest. 1981; 44(2):127-37. View

16.

Miller K, Dresner I, Michael A . Localization of platelet antigens in human kidney disease. Kidney Int. 1980; 18(4):472-9. DOI: 10.1038/ki.1980.160. View

17.

BERG B . SPONTANEOUS NEPHROSIS, WITH PROTEINURIA, HYPERGLOBULINEMIA, AND HYPERCHOLESTEROLEMIA IN THE RAT. Proc Soc Exp Biol Med. 1965; 119:417-20. DOI: 10.3181/00379727-119-30199. View