Influence of the Vagus Nerve Upon the Reflex Control of the Lower Oesophageal Sphincter

Overview

Journal Gut

Specialty Gastroenterology

Date 1984 Mar 1

PMID 6365699

Citations 8

Authors

A L OGILVIE

M Atkinson

Affiliations

Soon will be listed here.

Abstract

In 24 control patients the lower oesophageal sphincter responded to graded increments in intra-abdominal pressure by a significant and sustained rise in tone. This response was abolished by atropine and was also absent in nine of 11 patients who had previously undergone truncal vagotomy for duodenal ulcer but not in the remaining two who had recurrent ulceration. In six patients studied after proximal gastric vagotomy a variable response was seen. Gastric efferent vagal function was assessed by a combined insulin/pentagastrin gastric secretory test and did not correlate closely with the lower oesophageal sphincteric response to increased intra-gastric pressure. These findings are explicable if it is assumed that truncal vagotomy interrupts the afferent limb of a reflex arc regulating lower oesophageal sphincteric tone.

Citing Articles

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A new technique for measuring lower oesophageal sphincter competence in patients.

Byrne P, Stuart R, Lawlor P, Walsh T, Hennessy T Ir J Med Sci. 1993; 162(9):351-4.

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Influence of physical factors on the development of gastroesophageal reflux in man: analysis by means of an experimental mechanical model.

Gomez Sanz R, Moreno Gonzalez E, Seoane Gonzalez J, Vorwald Kuborn P, Maffettone V Dysphagia. 1994; 9(1):26-34.

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Does intrinsic LES tone increase as an adaptive response to increased intraabdominal pressure?.

Boyle J, Cohen S Dig Dis Sci. 1984; 29(8):760-1.

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Factors that influence induction of gastroesophageal reflux in normal human subjects.

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