Absence of Oligomeric Murein Intermediates in Escherichia Coli

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1983 Oct 1

PMID 6352672

Citations 9

Authors

E W Goodell

Z Markiewicz

U Schwarz

Affiliations

Soon will be listed here.

Abstract

The intermediates in the biosynthetic pathway of murein were examined in two strains of Escherichia coli to determine whether they synthesized oligomeric precursors in vivo. No oligomeric precursors could be detected; the only intermediates found were the previously described UDP-N-acetylmuramyl peptides, and the two lipid-linked compounds, N-acetylglucosamyl-N-acetylmuramyl-(pentapeptide)-pyrophosphoryl-undecaprenol and N-acetylmuramyl-(pentapeptide)-pyrophosphoryl-undecaprenol. It was concluded that lipid-linked monomers are directly incorporated into the murein sacculus in vivo and do not pass through an oligomeric stage.

Citing Articles

From the regulation of peptidoglycan synthesis to bacterial growth and morphology.

Typas A, Banzhaf M, Gross C, Vollmer W Nat Rev Microbiol. 2011; 10(2):123-36.

PMID: 22203377 PMC: 5433867. DOI: 10.1038/nrmicro2677.

Peptidoglycan hydrolases of Escherichia coli.

van Heijenoort J Microbiol Mol Biol Rev. 2011; 75(4):636-63.

PMID: 22126997 PMC: 3232740. DOI: 10.1128/MMBR.00022-11.

The architecture of the murein (peptidoglycan) in gram-negative bacteria: vertical scaffold or horizontal layer(s)?.

Vollmer W, Holtje J J Bacteriol. 2004; 186(18):5978-87.

PMID: 15342566 PMC: 515156. DOI: 10.1128/JB.186.18.5978-5987.2004.

Identification of a dedicated recycling pathway for anhydro-N-acetylmuramic acid and N-acetylglucosamine derived from Escherichia coli cell wall murein.

Park J J Bacteriol. 2001; 183(13):3842-7.

PMID: 11395446 PMC: 95265. DOI: 10.1128/JB.183.13.3842-3847.2001.

Growth of the stress-bearing and shape-maintaining murein sacculus of Escherichia coli.

Holtje J Microbiol Mol Biol Rev. 1998; 62(1):181-203.

PMID: 9529891 PMC: 98910. DOI: 10.1128/MMBR.62.1.181-203.1998.

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