Immunocytochemistry of Serotonin-containing Nerves in the Human Gut

Overview

Journal Histochemistry

Specialty Biochemistry

Date 1983 Jan 1

PMID 6352575

Citations 8

Authors

S S Kurian

G L Ferri

J de Mey

J M Polak

Affiliations

Soon will be listed here.

Abstract

An immunocytochemical technique, using L-tryptophan enhancement and paraformaldehyde fixation, has been successfully applied for the demonstration of serotonin-containing neurons in the human enteric nervous system. Throughout the intestine, serotonin-immunoreactive nerves were mainly detected in the myenteric plexus and, to a smaller extent, in the submucous plexus, while hardly any nerve fibres were seen in the mucosa. This approach provides a useful tool for the investigation of neuropathological conditions of the gut.

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