The Isolation and Characterization of a Mutant Strain of Saccharomyces Cerevisiae That Requires a Long Chain Base for Growth and for Synthesis of Phosphosphingolipids

Overview

Journal J Biol Chem

Specialty Biochemistry

Date 1983 Sep 10

PMID 6350287

Citations 41

Authors

G B Wells

R L Lester

Affiliations

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Abstract

A mutant of Saccharomyces cerevisiae has been obtained that shows an absolute growth requirement for long chain bases found in sphingolipids. In the absence of a long chain base, the cells are unable to synthesize the phosphoinositol-containing sphingolipids characteristic of yeast. These results suggest that one or more of the yeast sphingolipids plays a vital biological role.

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