Apurinic DNA Endonuclease Activities in Repair-deficient Human Cell Lines

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1978 Feb 1

PMID 634794

Citations 4

Authors

R E Moses

A L Beaudet

Affiliations

Soon will be listed here.

Abstract

Several autosomal recessive diseases are associated with apparent DNA repair defects in cell culture. It seemed likely that a defect in excision repair reported for ataxia telangiectasia cells might reflect a lack of apurinic endonuclease activity. We report here normal levels of apurinic endonuclease activity in extracts of cell lines derived from patients with ataxia telangiectasia, xeroderma pigmentosum (complementation group D), Cockayne dwarfism, Fanconi anemia and Bloom syndrome.

Citing Articles

Genetic and biochemical studies with ataxia telangiectasia. A review.

Huang P, Sheridan 3rd R Hum Genet. 1981; 59(1):1-9.

PMID: 10819014 DOI: 10.1007/BF00278846.

Isolation and characterization of monoclonal antibodies directed against the DNA repair enzyme uracil DNA glycosylase from human placenta.

Arenaz P, Sirover M Proc Natl Acad Sci U S A. 1983; 80(19):5822-6.

PMID: 6577457 PMC: 390167. DOI: 10.1073/pnas.80.19.5822.

Stable low molecular weight DNA in xeroderma pigmentosum cells.

Hurt M, Beaudet A, Moses R Proc Natl Acad Sci U S A. 1983; 80(22):6987-91.

PMID: 6196782 PMC: 390111. DOI: 10.1073/pnas.80.22.6987.

The response of ataxia telangiectasia cells to bleomycin.

Lehmann A, Stevens S Nucleic Acids Res. 1979; 6(5):1953-60.

PMID: 88042 PMC: 327823. DOI: 10.1093/nar/6.5.1953.

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