Current Status of Erythrocyte Substitutes

Overview

Journal Can Med Assoc J

Specialty General Medicine

Date 1983 Aug 1

PMID 6344974

Citations 1

Authors

G P Biro

Affiliations

Soon will be listed here.

Abstract

During the last two decades the search for alternatives to whole blood transfusions has led to promising developments in the field of erythrocyte substitutes. Hemoglobin solutions free of fragments of erythrocyte stroma and fluorocarbon emulsions are not blood-type-specific and appear likely to satisfy some proportion of our blood requirements. Both must be modified before becoming clinically useful. The oxygen affinity of the hemoglobin solution must be reduced and its intravascular persistence improved. Fluorocarbons cannot yet contribute significantly to the oxygen supply unless the patient breathes hyperbaric oxygen. Recent advances are leading to solutions for these problems.

Citing Articles

The safety of blood transfusions.

Schroeder M, Rayner H Can Fam Physician. 2011; 30:1803-6.

PMID: 21279095 PMC: 2154235.

References

CLARK Jr L, Gollan F . Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure. Science. 1966; 152(3730):1755-6. DOI: 10.1126/science.152.3730.1755. View

Haddy F . Physiology and pharmacology of the coronary circulation and myocardium, particularly in relation to coronary artery disease. Am J Med. 1969; 47(2):274-86. DOI: 10.1016/0002-9343(69)90153-3. View

RABINER S, OBrien K, PESKIN G, Friedman L . Further studies with stroma-free hemoglobin solution. Ann Surg. 1970; 171(4):615-22. PMC: 1396709. DOI: 10.1097/00000658-197004000-00020. View

Birndorf N, LOPAS H . Effects of red cell stroma-free hemoglobin solution on renal function in monkeys. J Appl Physiol. 1970; 29(5):573-8. DOI: 10.1152/jappl.1970.29.5.573. View

Braunwald E . Control of myocardial oxygen consumption: physiologic and clinical considerations. Am J Cardiol. 1971; 27(4):416-32. DOI: 10.1016/0002-9149(71)90439-5. View

Relihan M, Litwin M . Effects of stroma-free hemoglobin solution on clearance rate and renal function. Surgery. 1972; 71(3):395-9. View

Goodman M, Parrilla R, Toews C . Influence of fluorocarbon emulsions on hepatic metabolism in perfused rat liver. Am J Physiol. 1973; 225(6):1384-8. DOI: 10.1152/ajplegacy.1973.225.6.1384. View

Dixon D, Holland D . Fluorocarbons: properties and syntheses. Fed Proc. 1975; 34(6):1444-8. View

RABINER S . Hemoglobin solution as a plasma expander. Fed Proc. 1975; 34(6):1454-7. View

10.

Mok W, Chen D, Mazur A . Cross-linked hemoglobins as potential plasma protein extenders. Fed Proc. 1975; 34(6):1458-60. View

11.

KAPLAN H, Murthy V . Hemoglobin solution: a potential oxygen transporting plasma volume expander. Fed Proc. 1975; 34(6):1461-5. View

12.

Bonhard K . Acute oxygen supply by infusion of hemoglobin solutions. Fed Proc. 1975; 34(6):1466-7. View

13.

Brown H, Hardison W . Fluorocarbon liver perfusion and fluorocarbon-glycine interaction. Fed Proc. 1975; 34(6):1516-7. View

14.

SURGENOR D, Mierzwa B . Artificial blood and the National Blood Policy. Fed Proc. 1975; 34(6):1518-21. View

15.

McCONN R . The oxyhemoglobin dissociation curve in acute disease. Surg Clin North Am. 1975; 55(3):627-58. DOI: 10.1016/s0039-6109(16)40640-7. View

16.

Moss G, Dewoskin R, ROSEN A, Levine H, Palani C . Transport of oxygen and carbon dioxide by hemoglobin-saline solution in the red cell-free primate. Surg Gynecol Obstet. 1976; 142(3):357-62. View

17.

Tam S, Blumenstein J, Wong J . Soluble dextran-hemoglobin complex as a potential blood substitute. Proc Natl Acad Sci U S A. 1976; 73(6):2128-31. PMC: 430463. DOI: 10.1073/pnas.73.6.2128. View

18.

Novakova V . The evaluation of synthetic oxygen carriers by perfusion of isolated rat liver. Acta Physiol Scand. 1976; 98(4):433-9. DOI: 10.1111/j.1748-1716.1976.tb10332.x. View

19.

DE VENUTO F, Zuck T, Zegna A, Moores W . Characteristics of stroma-free hemoglobin prepared by crystallization. J Lab Clin Med. 1977; 89(3):509-16. View

20.

SAVITSKY J, Doczi J, Black J, Arnold J . A clinical safety trial of stroma-free hemoglobin. Clin Pharmacol Ther. 1978; 23(1):73-80. DOI: 10.1002/cpt197823173. View