Fasting Uric Acid and Phosphate in Urine and Plasma of Renal Calcium-stone Formers

Overview

Journal Nephron

Publisher Karger

Specialty Nephrology

Date 1976 Jan 1

PMID 634

Citations 9

Authors

P Schwille

N Samberger

B Wach

Affiliations

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Abstract

Clearance experiments in calcium-stone patients (n = 60) and controls (n = 60) demonstrated significantly higher urinary uric acid (UA) in younger (less 40 years) stone patients than controls (median: 480 vs. 351 mug/min) but not in older (greater than 40 years) patients. Serum UA and urinary oxypurines were comparable in health and stone disease. Conversely urinary phosphate was significantly lower in younger patients than matched controls (males: 224 vs. 304 mug) and presumably is responsible for the more alkaline pH. It is suggested that calcium-stone formation in humans is represented by two different populations.

Citing Articles

Urinary phosphate excretion in the pathophysiology of idiopathic recurrent calcium urolithiasis: hormonal interactions and lipid metabolism.

Schwille P, Herrmann U, Schmiedl A, Kissler H, Wipplinger J, Manoharan M Urol Res. 1997; 25(6):417-26.

PMID: 9443652 DOI: 10.1007/BF01268860.

Postprandial hyperinsulinaemia, insulin resistance and inappropriately high phosphaturia are features of younger males with idiopathic calcium urolithiasis: attenuation by ascorbic acid supplementation of a test meal.

Schwille P, Schmiedl A, Herrmann U, Wipplinger J Urol Res. 1997; 25(1):49-58.

PMID: 9079746 DOI: 10.1007/BF00941906.

Urinary excretion of urate in patients with calcium oxalate stone disease.

Tiselius H, Larsson L Urol Res. 1983; 11(6):279-83.

PMID: 6686365 DOI: 10.1007/BF00256347.

Idiopathic hypercalciuria. Urate and other ions in urine before and on various long term treatments.

Gill H, ROSE G Urol Res. 1985; 13(6):271-5.

PMID: 4095826 DOI: 10.1007/BF00262655.

Composition of renal stones and their frequency in a stone clinic: relationship to parameters of mineral metabolism in serum and urine.

Scholz D, Schwille P, Ulbrich D, Bausch W, Sigel A Urol Res. 1979; 7(3):161-70.

PMID: 505679 DOI: 10.1007/BF00257201.