Mechanism of Ribosome Frameshifting During Translation of the Genetic Code

Overview

Journal Nature

Specialty Science

Date 1983 Mar 6

PMID 6339944

Citations 38

Authors

R Weiss

J Gallant

Affiliations

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Abstract

Some frameshift mutations are strongly suppressed by limitation for particular aminoacyl-tRNA species. Here, we show that ribosome frameshifting at a specific tryptophan codon during Trp-tRNA limitation accounts for suppression of a group of downstream frameshift alleles in the rIIB gene of bacteriophage T4. Genetic and physiological observations strongly suggest that ribosome frameshifting at this position depends on the binding of a noncognate (leucine) tRNA.

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