Rabbit Monoarticular Arthritis As a Model for Intra-articular Drug Injections. The Local Action of Administered Cortisol and Alpha-1 Proteinase Inhibitor

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1984 Dec 1

PMID 6335819

Citations 1

Authors

E Pitt

D A Lewis

Affiliations

Soon will be listed here.

Abstract

Monoarticular arthritis in the rabbit has been used to study the effect of intra-articular administration of cortisol-21-phosphate and alpha-1-proteinase inhibitor. The preparations were administered both separately and in combination. All treatments improved parameters associated with joint biochemistry and histopathology, but the greatest effect was found when steroid was combined with anti-proteinase. Cortisol-21-phosphate had both an anti-inflammatory and anti-arthritic action, whereas alpha-1-proteinase inhibitor showed little anti-inflammatory action but had some anti-arthritic effect. Alpha-1-proteinase inhibitor had no anti-inflammatory action against carrageenan induced oedema in the rat, but was anti-arthritic against adjuvant induced arthritis in the rat where it reduced both primary and secondary arthritis.

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References

McGuire M, Murphy G, Reynolds J, Russell R . Production of collagenase and inhibitor (TIMP) by normal, rheumatoid and osteoarthritic synovium in vitro: effects of hydrocortisone and indomethacin. Clin Sci (Lond). 1981; 61(6):703-10. DOI: 10.1042/cs0610703. View

Hunneyball I . Some further effects of prednisolone and triamcinolone hexacetonide on experimental arthritis in rabbits. Agents Actions. 1981; 11(5):490-8. DOI: 10.1007/BF02004711. View

. Measurement of alpha 1-antitrypsin in serum, by immunodiffusion and by enzymatic assay. Clin Chem. 1974; 20(3):396-9. View

Dayer J, Breard J, Chess L, Krane S . Participation of monocyte-macrophages and lymphocytes in the production of a factor that stimulates collagenase and prostaglandin release by rheumatoid synovial cells. J Clin Invest. 1979; 64(5):1386-92. PMC: 371287. DOI: 10.1172/JCI109596. View

Dumonde D, GLYNN L . The production of arthritis in rabbits by an immunological reaction to fibrin. Br J Exp Pathol. 1962; 43:373-83. PMC: 2094309. View

NEWBOULD B . CHEMOTHERAPY OF ARTHRITIS INDUCED IN RATS BY MYCOBACTERIAL ADJUVANT. Br J Pharmacol Chemother. 1963; 21:127-36. PMC: 1703866. DOI: 10.1111/j.1476-5381.1963.tb01508.x. View

GLYNN L . Aetiology of rheumatoid arthritis with regard to its chronicity. Ann Rheum Dis. 1969; 28(5):Suppl:3-4. PMC: 2453469. View

SHTACHER G, Maayan R, FEINSTEIN G . Proteinase inhibitors in human synovial fluid. Biochim Biophys Acta. 1973; 303(1):138-47. DOI: 10.1016/0005-2795(73)90155-4. View

WINTER C, RISLEY E, NUSS G . Carrageenin-induced edema in hind paw of the rat as an assay for antiiflammatory drugs. Proc Soc Exp Biol Med. 1962; 111:544-7. DOI: 10.3181/00379727-111-27849. View

10.

Corbett M, Seifert M, Hacking C, Webb S . Comparison between local injections of silicone oil and hydrocortisone acetate in chronic arthritis. Br Med J. 1970; 1(5687):24-5. PMC: 1700899. DOI: 10.1136/bmj.1.5687.24. View

11.

GLYNN L . The chronicity of inflammation and its significance in rheumatoid arthritis. Ann Rheum Dis. 1968; 27(2):105-21. PMC: 1031077. DOI: 10.1136/ard.27.2.105. View

12.

Cochrane C . Plasma proteins and inflammatory disease. Pharmacol Rev. 1982; 34(1):39-42. View

13.

Rinderknecht H, GEOKAS M, Silverman P, HAVERBACK B . A new ultrasensitive method for the determination of proteolytic activity. Clin Chim Acta. 1968; 21(2):197-203. DOI: 10.1016/0009-8981(68)90127-7. View

14.

Kueppers F, Black L . Alpha1-antitrypsin and its deficiency. Am Rev Respir Dis. 1974; 110(2):176-94. DOI: 10.1164/arrd.1974.110.2.176. View

15.

Atkinson D, Hicks R . Relationship between the anti-inflammatory and irritant properties of inflammatory exudate. Br J Pharmacol. 1971; 41(3):480-7. PMC: 1702859. DOI: 10.1111/j.1476-5381.1971.tb08045.x. View

16.

Hirata F, Del Carmine R, Nelson C, Axelrod J, Schiffmann E, Warabi A . Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases. Proc Natl Acad Sci U S A. 1981; 78(5):3190-4. PMC: 319526. DOI: 10.1073/pnas.78.5.3190. View

17.

Lieberman J, Kaneshiro W . Inhibition of leukocytic elastase from purulent sputum by alpha 1 -antitrypsin. J Lab Clin Med. 1972; 80(1):88-101. View

18.

Brackertz D . [Proteinase inhibitors in rheumatic diseases]. Dtsch Med Wochenschr. 1978; 103(46):1844-9. DOI: 10.1055/s-0028-1129355. View

19.

Maguire E, Wallis R . The role of bacterial contamination in the isolation of apparent anti-inflammatory factors from rabbit anti-lymphocytic serum. Br J Pharmacol. 1977; 59(2):261-8. PMC: 1667729. DOI: 10.1111/j.1476-5381.1977.tb07488.x. View

20.

LAURELL C, Pierce J, Persson U, Thulin E . Purification of alpha1-antitrypsin from plasma through thiol-disulfide interchange. Eur J Biochem. 1975; 57(1):107-13. DOI: 10.1111/j.1432-1033.1975.tb02281.x. View