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Induction of Anti-nuclear Antibodies by Mercuric Chloride in Mice

Overview
Journal Clin Exp Immunol
Publisher Oxford University Press
Specialty Allergy & Immunology
Date 1984 Nov 1
PMID 6333944
Citations 20
Authors
C J Robinson
A A Abraham
T Balazs
Affiliations
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Abstract

Mercuric chloride (HgCl2) was administered parenterally to outbred Swiss ICR mice of both sexes and to inbred A/J male mice. In repeated experiments both male and female ICR mice developed anti-nuclear antibodies (ANA) giving a distinctive nucleolar fluorescence pattern in response to HgCl2 treatment. Within 1 week after the start of treatment, many of the mice had serum ANA of the IgG class directed against nucleolar antigen(s). Maximum ANA induction was reached by week 4. Inbred A/J male mice were resistant to the induction of ANA by HgCl2.

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