Cellular Transformation by Human Papillomavirus DNA in Vitro

Overview

Journal Science

Specialty Science

Date 1984 Aug 10

PMID 6330900

Citations 22

Authors

S L Watts

W C Phelps

R S Ostrow

K R Zachow

A J Faras

Affiliations

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Abstract

Molecularly cloned DNA's of human papillomaviruses HPV-5 and HPV-l induced morphological transformation of mouse C127 cells in culture. Single-cell clones of cells transformed by papillomavirus contained multiple persistent episomal copies of the transfected DNA species and were analyzed for growth characteristics indicating malignant potential.

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