Photoalteration of Calcium Channel Blockade in the Cardiac Purkinje Fiber

Overview

Journal Biophys J

Publisher Cell Press

Specialty Biophysics

Date 1984 May 1

PMID 6329345

Citations 10

Authors

M C Sanguinetti

R S Kass

Affiliations

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Abstract

Organic compounds that block calcium channel current (calcium antagonists) are important tools for the characterization of this channel. However, the practically irreversible nature of this block restricts the usefulness of this group of drugs. In this paper, we investigate the influence of light on calcium channel blockade by several organic compounds. Our results show that inhibition of calcium channel current by two dihydropyridine derivatives that contain an o-nitro moiety (nisoldipine and nifedipine) can be rapidly reversed by illumination. The energy range important to this reaction is for light wavelengths between 320 and 450 nm. Calcium channel inhibition by two other dihydropyridine derivatives (nicardipine and nitrendipine) as well as by D600, is not modulated by illumination. These results indicate that the photosensitivity of certain dihydropyridine calcium channel blockers make these compounds useful as reversible blockers of this channel.

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References

Henry P . Comparative pharmacology of calcium antagonists: nifedipine, verapamil and diltiazem. Am J Cardiol. 1980; 46(6):1047-58. DOI: 10.1016/0002-9149(80)90366-5. View

Kass R . Nisoldipine: a new, more selective calcium current blocker in cardiac Purkinje fibers. J Pharmacol Exp Ther. 1982; 223(2):446-56. View

Reuter H . Properties of two inward membrane currents in the heart. Annu Rev Physiol. 1979; 41:413-24. DOI: 10.1146/annurev.ph.41.030179.002213. View

FLECKENSTEIN A . Specific pharmacology of calcium in myocardium, cardiac pacemakers, and vascular smooth muscle. Annu Rev Pharmacol Toxicol. 1977; 17:149-66. DOI: 10.1146/annurev.pa.17.040177.001053. View

Brown A, Morimoto K, Tsuda Y, Wilson D . Calcium current-dependent and voltage-dependent inactivation of calcium channels in Helix aspersa. J Physiol. 1981; 320:193-218. PMC: 1244042. DOI: 10.1113/jphysiol.1981.sp013944. View

Lee K, Tsien R . Mechanism of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells. Nature. 1983; 302(5911):790-4. DOI: 10.1038/302790a0. View

Fenwick E, Marty A, Neher E . Sodium and calcium channels in bovine chromaffin cells. J Physiol. 1982; 331:599-635. PMC: 1197771. DOI: 10.1113/jphysiol.1982.sp014394. View

Kass R, Tsien R . Multiple effects of calcium antagonists on plateau currents in cardiac Purkinje fibers. J Gen Physiol. 1975; 66(2):169-92. PMC: 2226200. DOI: 10.1085/jgp.66.2.169. View

Kass R, Scheuer T, Malloy K . Block of outward current in cardiac Purkinje fibers by injection of quaternary ammonium ions. J Gen Physiol. 1982; 79(6):1041-63. PMC: 2216454. DOI: 10.1085/jgp.79.6.1041. View

10.

Siegelbaum S, Tsien R . Calcium-activated transient outward current in calf cardiac Purkinje fibres. J Physiol. 1980; 299:485-506. PMC: 1279238. DOI: 10.1113/jphysiol.1980.sp013138. View

11.

Oxford G, Pooler J . Ultraviolet photoalteration of ion channels in voltage-clamped lobster giant axons. J Membr Biol. 1975; 20(1-2):13-30. DOI: 10.1007/BF01870625. View

12.

Kass R . An optical monitor of tension for small cardiac preparations. Biophys J. 1981; 34(1):165-70. PMC: 1327460. DOI: 10.1016/S0006-3495(81)84843-6. View

13.

Ehlert F, Roeske W, Itoga E, Yamamura H . The binding of [3H]nitrendipine to receptors for calcium channel antagonists in the heart, cerebral cortex, and ileum of rats. Life Sci. 1982; 30(25):2191-202. DOI: 10.1016/0024-3205(82)90293-4. View

14.

Hagiwara S, Byerly L . Calcium channel. Annu Rev Neurosci. 1981; 4:69-125. DOI: 10.1146/annurev.ne.04.030181.000441. View

15.

Fox J, Stampfli R . Modification of ionic membrane currents of Ranvier nodes by UV-radiation under voltage clamp conditions. Experientia. 1971; 27(11):1289-90. DOI: 10.1007/BF02136692. View

16.

Ebel S, Schutz H, Hornitschek A . [Studies on the analysis of nifedipine considering in particular transformation products formed by light exposition (author's transl)]. Arzneimittelforschung. 1978; 28(12):2188-93. View

17.

Reuter H . Calcium channel modulation by neurotransmitters, enzymes and drugs. Nature. 1983; 301(5901):569-74. DOI: 10.1038/301569a0. View

18.

Corson D, Goodman S, Fein A . An adaptation of the jet stream microelectrode beveler. Science. 1979; 205(4412):1302. DOI: 10.1126/science.205.4412.1302-a. View

19.

Kass R, Siegelbaum S, Tsien R . Incomplete inactivation of the slow inward current in cardiac Purkinje fibres [proceedings]. J Physiol. 1976; 263(1):127P-128P. View

20.

Morad M, Goldman Y, Trentham D . Rapid photochemical inactivation of Ca2+-antagonists shows that Ca2+ entry directly activates contraction in frog heart. Nature. 1983; 304(5927):635-8. DOI: 10.1038/304635a0. View