The Human Myoglobin Gene: a Third Dispersed Globin Locus in the Human Genome

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1984 Apr 11

PMID 6326055

Citations 3

Authors

A J Jeffreys

V Wilson

A Blanchetot

P Weller

A Geurts van Kessel

N Spurr

E Solomon

P Goodfellow

Affiliations

Soon will be listed here.

Abstract

Human myoglobin is specified by a single gene. Unique sequence DNA probes were isolated from the cloned gene and used to test for the presence of the human myoglobin gene in a series of human rodent somatic cell hybrids containing various complements of human chromosomes. The myoglobin gene cosegregated with human chromosome 22. Somatic cell hybrids containing translocation chromosomes carrying part of chromosome 22 were used to locate the myoglobin gene to the region 22q11----22q13. The myoglobin gene is therefore not linked to the alpha-globin gene cluster on chromosome 16 or the beta-globin cluster on chromosome 11, and represents a third dispersed globin locus in the human genome.

Citing Articles

Profile of Alec J. Jeffreys.

Zagorski N Proc Natl Acad Sci U S A. 2006; 103(24):8918-20.

PMID: 16754883 PMC: 1482540. DOI: 10.1073/pnas.0603953103.

Human chromosome 22.

Kaplan J, Aurias A, Julier C, PRIEUR M, Szajnert M J Med Genet. 1987; 24(2):65-78.

PMID: 3550088 PMC: 1049892. DOI: 10.1136/jmg.24.2.65.

A linkage and physical map of chromosome 22, and some applications to gene mapping.

Julier C, Lathrop G, Reghis A, Szajnert M, Lalouel J, Kaplan J Am J Hum Genet. 1988; 42(2):297-308.

PMID: 2893546 PMC: 1715259.

References

Jeffreys A . DNA sequence variants in the G gamma-, A gamma-, delta- and beta-globin genes of man. Cell. 1979; 18(1):1-10. DOI: 10.1016/0092-8674(79)90348-9. View

Efstratiadis A, Posakony J, Maniatis T, Lawn R, OConnell C, Spritz R . The structure and evolution of the human beta-globin gene family. Cell. 1980; 21(3):653-68. DOI: 10.1016/0092-8674(80)90429-8. View

Goodfellow P, Banting G, Levy R, Povey S, McMichael A . A human X-linked antigen defined by a monoclonal antibody. Somatic Cell Genet. 1980; 6(6):777-87. DOI: 10.1007/BF01538976. View

Dretzen G, BELLARD M, Sassone-Corsi P, Chambon P . A reliable method for the recovery of DNA fragments from agarose and acrylamide gels. Anal Biochem. 1981; 112(2):295-8. DOI: 10.1016/0003-2697(81)90296-7. View

Bernheim A, Berger R, Lenoir G . Cytogenetic studies on African Burkitt's lymphoma cell lines: t(8;14), t(2;8) and t(8;22) translocations. Cancer Genet Cytogenet. 1981; 3(4):307-15. DOI: 10.1016/0165-4608(81)90039-x. View

Andrews P, Knowles B, Goodfellow P . A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12. Somatic Cell Genet. 1981; 7(4):435-43. DOI: 10.1007/BF01542988. View

Erikson J, Martinis J, Croce C . Assignment of the genes for human lambda immunoglobulin chains to chromosome 22. Nature. 1981; 294(5837):173-5. DOI: 10.1038/294173a0. View

Barton P, Malcolm S, Murphy C, Ferguson-Smith M . Localization of the human alpha-globin gene cluster to the short arm of chromosome 16 (16p12-16pter) by hybridization in situ. J Mol Biol. 1982; 156(2):269-78. DOI: 10.1016/0022-2836(82)90328-x. View

Czelusniak J, Goodman M, Weiss M, Venta P, TASHIAN R . Phylogenetic origins and adaptive evolution of avian and mammalian haemoglobin genes. Nature. 1982; 298(5871):297-300. DOI: 10.1038/298297a0. View

10.

Heisterkamp N, Groffen J, Stephenson J, Spurr N, Goodfellow P, Solomon E . Chromosomal localization of human cellular homologues of two viral oncogenes. Nature. 1982; 299(5885):747-9. DOI: 10.1038/299747a0. View

11.

Dalla-Favera R, Gallo R, Giallongo A, Croce C . Chromosomal localization of the human homolog (c-sis) of the simian sarcoma virus onc gene. Science. 1982; 218(4573):686-8. DOI: 10.1126/science.6291150. View

12.

de Klein A, Van Kessel A, Grosveld G, Bartram C, Hagemeijer A, BOOTSMA D . A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982; 300(5894):765-7. DOI: 10.1038/300765a0. View

13.

Rowley J . Human oncogene locations and chromosome aberrations. Nature. 1983; 301(5898):290-1. DOI: 10.1038/301290a0. View

14.

Wood D, Blanchetot A, Jeffreys A . Molecular cloning of seal myoglobin mRNA. Nucleic Acids Res. 1982; 10(22):7133-44. PMC: 326993. DOI: 10.1093/nar/10.22.7133. View

15.

TAUB R, Kirsch I, Morton C, Lenoir G, Swan D, Tronick S . Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci U S A. 1982; 79(24):7837-41. PMC: 347444. DOI: 10.1073/pnas.79.24.7837. View

16.

Hosbach H, Wyler T, Weber R . The Xenopus laevis globin gene family: chromosomal arrangement and gene structure. Cell. 1983; 32(1):45-53. DOI: 10.1016/0092-8674(83)90495-6. View

17.

Blanchetot A, Wilson V, Wood D, Jeffreys A . The seal myoglobin gene: an unusually long globin gene. Nature. 1983; 301(5902):732-4. DOI: 10.1038/301732a0. View

18.

de Martinville B, Francke U . The c-Ha-ras1, insulin and beta-globin loci map outside the deletion associated with aniridia-Wilms' tumour. Nature. 1983; 305(5935):641-3. DOI: 10.1038/305641a0. View

19.

Westerveld A, Naylor S . Report of the Committee on the Genetic Constitution of Chromosomes 18, 19, 20, 21, and 22. Cytogenet Cell Genet. 1984; 37(1-4):155-75. DOI: 10.1159/000132008. View

20.

Weller P, Jeffreys A, Wilson V, Blanchetot A . Organization of the human myoglobin gene. EMBO J. 1984; 3(2):439-46. PMC: 557363. DOI: 10.1002/j.1460-2075.1984.tb01825.x. View