Structure of a Human Gastrin Gene

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1984 Feb 1

PMID 6322186

Citations 19

Authors

O Wiborg

L Berglund

E Boel

F Norris

K Norris

J F Rehfeld

K A Marcker

J Vuust

Affiliations

Soon will be listed here.

Abstract

A gastrin gene was isolated from a genomic library of human DNA. The human gastrin gene is about 4100 base pairs long and contains two intervening sequences. Thus, a 3500-base-pair intervening sequence is located 5 base pairs proximal to the ATG initiator codon, while a 129-base-pair intervening sequence separates the region coding for the principal hormonal form of gastrin, the heptadecapeptide, from the region coding for the major amino-terminal portion of the gastrin precursor. The 5' flanking region of the gene contains the conserved sequences, T-A-T-A-A and G-A-C-T-C-A-T-A-T, in positions similar to those of other eukaryotic genes.

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