Von Willebrand Protein Binds to Extracellular Matrices Independently of Collagen

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1984 Jan 1

PMID 6320190

Citations 13

Authors

D D Wagner

V J Marder

Affiliations

Soon will be listed here.

Abstract

Von Willebrand protein is present in the extracellular matrix of endothelial cells where it codistributes with fibronectin and types IV and V collagen. Bacterial collagenase digestion of endothelial cells removed fibrillar collagen, but the pattern of fibronectin and of von Willebrand protein remained undisturbed. Exogenous von Willebrand protein bound to matrices of different cells, whether rich or poor in collagen. von Willebrand protein also decorated the matrix of cells grown in the presence of alpha, alpha'-dipyridyl, a collagen-secretion inhibitor. These results indicate that the presence of von Willebrand protein in the extracellular matrix of endothelial cells and the binding of von Willebrand protein to foreign matrices do not depend on the matrix collagen.

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References

Jaffe E, HOYER L, Nachman R . Synthesis of antihemophilic factor antigen by cultured human endothelial cells. J Clin Invest. 1973; 52(11):2757-64. PMC: 302543. DOI: 10.1172/JCI107471. View

SAGE H . Collagens of basement membranes. J Invest Dermatol. 1982; 79 Suppl 1:51s-59s. DOI: 10.1111/1523-1747.ep12545773. View

Jenkins C, Phillips D, Clemetson K, Meyer D, LARRIEU M, LUSCHER E . Platelet membrane glycoproteins implicated in ristocetin-induced aggregation. Studies of the proteins on platelets from patients with Bernard-Soulier syndrome and von Willebrand's disease. J Clin Invest. 1976; 57(1):112-24. PMC: 436631. DOI: 10.1172/JCI108251. View

Wagner D, Olmsted J, Marder V . Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells. J Cell Biol. 1982; 95(1):355-60. PMC: 2112360. DOI: 10.1083/jcb.95.1.355. View

Caen J, Nurden A, Jeanneau C, Michel H, Tobelem G, Levy-Toledano S . Bernard-Soulier syndrome: a new platelet glycoprotein abnormality. Its relationship with platelet adhesion to subendothelium and with the factor VIII von Willebrand protein. J Lab Clin Med. 1976; 87(4):586-96. View

Sakariassen K, Bolhuis P, Sixma J . Human blood platelet adhesion to artery subendothelium is mediated by factor VIII-Von Willebrand factor bound to the subendothelium. Nature. 1979; 279(5714):636-8. DOI: 10.1038/279636a0. View

Alitalo K, Myllyla R, SAGE H, Pritzl P, Vaheri A, Bornstein P . Biosynthesis of type V procollagen by A204, a human rhabdomyosarcoma cell line. J Biol Chem. 1982; 257(15):9016-24. View

Raugi G, Mumby S, Bornstein P . Thrombospondin: synthesis and secretion by cells in culture. J Cell Biol. 1982; 95(1):351-4. PMC: 2112350. DOI: 10.1083/jcb.95.1.351. View

Coller B, Peerschke E, Scudder L, Sullivan C . Studies with a murine monoclonal antibody that abolishes ristocetin-induced binding of von Willebrand factor to platelets: additional evidence in support of GPIb as a platelet receptor for von Willebrand factor. Blood. 1983; 61(1):99-110. View

10.

PERKINS M, Ji T, Hynes R . Cross-linking of fibronectin to sulfated proteoglycans at the cell surface. Cell. 1979; 16(4):941-52. DOI: 10.1016/0092-8674(79)90109-0. View

11.

Martin S, Marder V, Francis C, Loftus L, BARLOW G . Enzymatic degradation of the factor-VIII-von-Willebrand protein: a unique tryptic fragment with ristocetin cofactor activity. Blood. 1980; 55(5):848-58. View

12.

Rand J, Gordon R, Sussman I, Chu S, Solomon V . Electron microscopic localization of factor-VIII-related antigen in adult human blood vessels. Blood. 1982; 60(3):627-34. View

13.

Rand J, Sussman I, Gordon R, Chu S, Solomon V . Localization of factor-VIII-related antigen in human vascular subendothelium. Blood. 1980; 55(5):752-6. View

14.

Hynes R, HUMPHRYES K . Characterization of the external proteins of hamster fibroblasts. J Cell Biol. 1974; 62(2):438-48. PMC: 2109387. DOI: 10.1083/jcb.62.2.438. View

15.

ZUCKER M, Broekman M, Kaplan K . Factor VIII-related antigen in human blood platelets: localization and release by thrombin and collagen. J Lab Clin Med. 1979; 94(5):675-82. View

16.

Hayman E, Oldberg A, Martin G, Ruoslahti E . Codistribution of heparan sulfate proteoglycan, laminin, and fibronectin in the extracellular matrix of normal rat kidney cells and their coordinate absence in transformed cells. J Cell Biol. 1982; 94(1):28-35. PMC: 2112187. DOI: 10.1083/jcb.94.1.28. View

17.

HOYER L . The factor VIII complex: structure and function. Blood. 1981; 58(1):1-13. View

18.

Hynes R, Destree A . Relationships between fibronectin (LETS protein) and actin. Cell. 1978; 15(3):875-86. DOI: 10.1016/0092-8674(78)90272-6. View

19.

Fay P, Chavin S, Schroeder D, Young F, Marder V . Purification and characterization of a highly purified human factor VIII consisting of a single type of polypeptide chain. Proc Natl Acad Sci U S A. 1982; 79(23):7200-204. PMC: 347306. DOI: 10.1073/pnas.79.23.7200. View

20.

Koutts J, Walsh P, Plow E, Fenton 2nd J, Bouma B, ZIMMERMAN T . Active release of human platelet factor VIII-related antigen by adenosine diphosphate, collagen, and thrombin. J Clin Invest. 1978; 62(6):1255-63. PMC: 371891. DOI: 10.1172/JCI109246. View