Presentation of Benzo(a)pyrene to Microsomal Enzymes by Asbestos Fibers in the Salmonella/mammalian Microsome Mutagenicity Test

Overview

Journal Environ Health Perspect

Date 1983 Sep 1

PMID 6315376

Citations 1

Authors

K Szyba

A Lange

Affiliations

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Abstract

The potential effect of asbestos fibers on mutagenicity of benzo(a)pyrene was investigated by using the Ames test. Asbestos fibers without a coating of benzo(a)pyrene or benzo(a)pyrene when not dissolved in DMSO lacked any mutagenic effect in the Salmonella/mammalian microsome mutagenicity test. However, when benzo(a)pyrene was adsorbed onto asbestos, significant numbers of mutated bacteria were observed. This shows that asbestos fibers can serve a carrier role presenting benzo(a)pyrene to the enzymatic microsomal system, thus enhancing mutagenicity of this compound.

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