[Beta-adrenergic Receptors and Plasma Catecholamine Behavior in Trained and Untrained Athletes]

Overview

Journal Klin Wochenschr

Specialty General Medicine

Date 1983 Sep 1

PMID 6314035

Citations 7

Authors

M Lehmann

P Schmid

H Porzig

J KEUL

Affiliations

Soon will be listed here.

Abstract

6 sports students (VO2 max. 54.0 +/- 2.6 ml/kg . min) and 6 marathoners (VO2 max. 65.7 +/- 2.0 ml/kg . min) performed graded treadmill tests. Free plasma catecholamines (noradrenaline and adrenaline), heart rate, lactate were assessed at rest and during exercise. The behaviour of beta-adrenergic receptors of polymorphonuclear leukocytes was estimated additionally before the treadmill test. The maximum running velocity was 14.6 +/- 0.8 km/h (sports students) and 17.3 +/- 0.6 km/h (marathoners). Noradrenaline was approximately 46% (v = 12 km/h) to 67% (v = 14 km/h) lower in the group of marathoners than in sports students; adrenaline showed no or smaller differences between both groups. No significant differences in the plasma catecholamine behaviour occurred between the groups at rest and during maximum exercise. Specific binding of 3H-Dihydroalprenolol to intact cells was higher in the marathoners than in sports students (p greater than 0.01). Scatchard analysis revealed a maximum binding of 21.1 fmol/10(7) cells (sports students) and 35.3 fmol/10(7) cells (marathoners), which indicated approximately 1,300 (sports students) and 2,150 binding sites cell (marathoners). Inverse correlations between noradrenaline (r = -0.63), VO2max. (r = -0.79) and the specific binding of 3H-DHA were observed. The reduction of plasma catecholamines (approximately 46-67%) and the increase in specific binding sites (approximately 67%) were in the same range.(ABSTRACT TRUNCATED AT 250 WORDS)

Citing Articles

Exercise training bradycardia is largely explained by reduced intrinsic heart rate.

Bahrainy S, Levy W, Busey J, Caldwell J, Stratton J Int J Cardiol. 2016; 222:213-216.

PMID: 27497097 PMC: 5042852. DOI: 10.1016/j.ijcard.2016.07.203.

Assessment of the Effects of Age, Gender, and Exercise Training on the Cardiac Sympathetic Nervous System Using Positron Emission Tomography Imaging.

Bernacki G, Bahrainy S, Caldwell J, Levy W, Link J, Stratton J J Gerontol A Biol Sci Med Sci. 2016; 71(9):1195-201.

PMID: 26957471 PMC: 4978358. DOI: 10.1093/gerona/glw020.

[Is the alpha adrenergic receptor density increased in intact thrombocytes in non-isometric trained athletes?].

Lehmann M, Schmid P, Bergdolt E, Jakob E, Spori U, KEUL J Klin Wochenschr. 1984; 62(20):992-5.

PMID: 6094909 DOI: 10.1007/BF01728430.

[Conjugated plasma catecholamines are lower in power athletes at rest and in physical work than in untrained probands].

Lehmann M, KEUL J Klin Wochenschr. 1985; 63(1):37-42.

PMID: 3974173 DOI: 10.1007/BF01537485.

Lehmann M, Berg A, KEUL J Eur J Appl Physiol Occup Physiol. 1986; 55(1):54-8.

PMID: 3698988 DOI: 10.1007/BF00422893.

References

Baer M, Porzig H . Cell metabolism affects the density of beta-adrenergic receptors in intact rat reticulocytes. FEBS Lett. 1980; 111(1):205-8. DOI: 10.1016/0014-5793(80)80794-0. View

Maurer W, Yoshida Y, Kubler W . [Urinary excretion of the catecholamines adrenaline, noradrenaline and dopamine as well as the derivatives metanephrine and normetanephrine in heart disease patients]. Z Kardiol. 1976; 65(12):1124-38. View

Bristow M, Ginsburg R, Minobe W, Cubicciotti R, Sageman W, Lurie K . Decreased catecholamine sensitivity and beta-adrenergic-receptor density in failing human hearts. N Engl J Med. 1982; 307(4):205-11. DOI: 10.1056/NEJM198207223070401. View

Hagberg J, Hickson R, McLane J, Ehsani A, Winder W . Disappearance of norepinephrine from the circulation following strenuous exercise. J Appl Physiol Respir Environ Exerc Physiol. 1979; 47(6):1311-4. DOI: 10.1152/jappl.1979.47.6.1311. View

Tipton C, Matthes R, Tcheng T, Dowell R, Vailas A . The use of the Langendorff preparation to study the bardycardia of training. Med Sci Sports. 1977; 9(4):220-30. View

LeBlanc J, Boulay M, Dulac S, Jobin M, Labrie A . Metabolic and cardiovascular responses to norepinephrine in trained and nontrained human subjects. J Appl Physiol Respir Environ Exerc Physiol. 1977; 42(2):166-73. DOI: 10.1152/jappl.1977.42.2.166. View

SARNOFF S, Braunwald E, WELCH Jr G, CASE R, STAINSBY W, Macruz R . Hemodynamic determinants of oxygen consumption of the heart with special reference to the tension-time index. Am J Physiol. 1958; 192(1):148-56. DOI: 10.1152/ajplegacy.1957.192.1.148. View

Heiss H, Barmeyer J, Wink K, Hell G, Cerny F, KEUL J . Studies on the regulation of myocardial blood flow in man. I.: Training effects on blood flow and metabolism of the healthy heart at rest and during standardized heavy exercise. Basic Res Cardiol. 1976; 71(6):658-75. DOI: 10.1007/BF01906411. View

Ekblom B, Kilbom A, Soltysiak J . Physical training, bradycardia, and autonomic nervous system. Scand J Clin Lab Invest. 1973; 32(3):251-6. DOI: 10.3109/00365517309082468. View

10.

Boyum A . Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g. Scand J Clin Lab Invest Suppl. 1968; 97:77-89. View

11.

Stone H . The unanesthetized instrumented animal preparation. Med Sci Sports. 1977; 9(4):253-61. View

12.

Hertting G . [The sympathetic neuron: regulation mechanisms for transmitter synthesis, transmitter release, and stimulus response (author's transl)]. Klin Wochenschr. 1979; 57(12):593-8. DOI: 10.1007/BF01477625. View

13.

HARTLEY L, Mason J, Hogan R, JONES L, Kotchen T, MOUGEY E . Multiple hormonal responses to prolonged exercise in relation to physical training. J Appl Physiol. 1972; 33(5):607-10. DOI: 10.1152/jappl.1972.33.5.607. View

14.

Braunwald E . THE CONTROL OF VENTRICULAR FUNCTION IN MAN. Br Heart J. 1965; 27:1-16. PMC: 490129. DOI: 10.1136/hrt.27.1.1. View

15.

Lehmann M, KEUL J, Lollgen H, Just H . [Plasma catecholamines and hemodynamics in left heart failure (author's transl)]. Z Kardiol. 1981; 70(4):238-44. View

16.

Winder W, Hagberg J, Hickson R, Ehsani A, McLane J . Time course of sympathoadrenal adaptation to endurance exercise training in man. J Appl Physiol Respir Environ Exerc Physiol. 1978; 45(3):370-4. DOI: 10.1152/jappl.1978.45.3.370. View

17.

Lehmann M, Dickhuth H, Stamer S, Spielberger B, KEUL J . [Varying cardiac and metabolic effects of isoproterenol relative to the condition of physical training]. Klin Wochenschr. 1983; 61(11):567-75. DOI: 10.1007/BF01486847. View

18.

Porzig H, Baer M, Chanton C . Properties of beta-adrenoceptor sites in metabolizing and nonmetabolizing rat reticulocytes and in resealed reticulocyte ghosts. Naunyn Schmiedebergs Arch Pharmacol. 1981; 317(4):286-93. DOI: 10.1007/BF00501308. View

19.

Winder W, Hickson R, Hagberg J, Ehsani A, McLane J . Training-induced changes in hormonal and metabolic responses to submaximal exercise. J Appl Physiol Respir Environ Exerc Physiol. 1979; 46(4):766-71. DOI: 10.1152/jappl.1979.46.4.766. View

20.

Francis G, Goldsmith S, Cohn J . Relationship of exercise capacity to resting left ventricular performance and basal plasma norepinephrine levels in patients with congestive heart failure. Am Heart J. 1982; 104(4 Pt 1):725-31. DOI: 10.1016/0002-8703(82)90003-5. View