Nonspecific Suppressive Effect of Bovine Herpesvirus Type 1 on Bovine Leukocyte Functions

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1983 Oct 1

PMID 6311742

Citations 11

Authors

L G Filion

R L McGuire

L A Babiuk

Affiliations

Soon will be listed here.

Abstract

The effect of bovine herpesvirus type 1 on the specific and nonspecific immune response of calves was examined. Animals with or without prior aerosol exposure to Pasteurella haemolytica serotype A1 were aerosol challenged with 10(8) PFU of virus. Blood and serum samples were taken before and after virus challenge for determining cell-mediated, humoral, and neutrophil responses. A significant depression of the blastogenic responses to phytohemagglutinin, P. haemolytica, and Pasteurella multocida and of neutrophil chemotactic response was observed 4 to 7 days after challenge. However, the antibacterial activity of neutrophils was not significantly affected by virus exposure. Anti-bovine herpesvirus type 1 antibody responses were detected 11 days postchallenge. A significant elevation of the anti-P. haemolytica antibody response (day 0 versus day +11) was detected in animals previously exposed to P. haemolytica.

Citing Articles

Evaluation of Hematological Profiles and Monocyte Subpopulations in Water Buffalo Calves after Immunization with Two Different IBR Marker Vaccines and Subsequent Infection with -1.

Grandoni F, Hussen J, Signorelli F, Napolitano F, Scata M, De Donato I Vaccines (Basel). 2023; 11(9).

PMID: 37766082 PMC: 10537172. DOI: 10.3390/vaccines11091405.

Attachment but not penetration of bovine herpesvirus 1 is necessary to induce apoptosis in target cells.

Hanon E, Meyer G, Vanderplasschen A, Thiry E, Pastoret P J Virol. 1998; 72(9):7638-41.

PMID: 9696867 PMC: 110026. DOI: 10.1128/JVI.72.9.7638-7641.1998.

Inactivated bovine herpesvirus 1 induces apoptotic cell death of mitogen-stimulated bovine peripheral blood mononuclear cells.

Hanon E, Vanderplasschen A, Lyaku S, Keil G, Denis M, Pastoret P J Virol. 1996; 70(6):4116-20.

PMID: 8648752 PMC: 190298. DOI: 10.1128/JVI.70.6.4116-4120.1996.

The possible role of stress in the induction of pneumonic pasteurellosis.

Filion L, Willson P, Bielefeldt-Ohmann H, Babiuk L, Thomson R Can J Comp Med. 1984; 48(3):268-74.

PMID: 6089981 PMC: 1236058.

Comparison of serological techniques to measure antibody to Pasteurella haemolytica A1.

Filion L, Cho H, Shewen P, Raybould T, Wilkie B Can J Comp Med. 1985; 49(1):99-103.

PMID: 3986685 PMC: 1236126.

References

Fireman P, Friday G, Kumate J . Effect of measles vaccine on immunologic responsiveness. Pediatrics. 1969; 43(2):264-72. View

Notkins A, Mergenhagen S, Howard R . Effect of virus infections on the function of the immune system. Annu Rev Microbiol. 1970; 24:525-38. DOI: 10.1146/annurev.mi.24.100170.002521. View

REED W, Olds J, KISCH A . Decreased skin-test reactivity associated with influenza. J Infect Dis. 1972; 125(4):398-402. DOI: 10.1093/infdis/125.4.398. View

Kauffman C, Phair J, Linnemann Jr C, Schiff G . Cell-mediated immunity in humans during viral infection. I. Effect of rubella on dermal hypersensitivity, phytohemagglutinin response, and T lymphocyte numbers. Infect Immun. 1974; 10(1):212-5. PMC: 414979. DOI: 10.1128/iai.10.1.212-215.1974. View

Mangi R, Niederman J, Kelleher Jr J, Dwyer J, Evans A, Kantor F . Depression of cell-mediated immunity during acute infectious mononucleosis. N Engl J Med. 1974; 291(22):1149-53. DOI: 10.1056/NEJM197411282912202. View

Kantor F . Infection, anergy and cell-mediated immunity. N Engl J Med. 1975; 292(12):629-34. DOI: 10.1056/NEJM197503202921210. View

JOHNSTON Jr R, Keele Jr B, Misra H, Lehmeyer J, Webb L, Baehner R . The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes. J Clin Invest. 1975; 55(6):1357-72. PMC: 301891. DOI: 10.1172/JCI108055. View

Jakab G . Suppression of pulmonary antibacterial activity following Sendai virus infection in mice: dependence on virus dose. Arch Virol. 1975; 48(4):385-90. DOI: 10.1007/BF01317437. View

Howard R, Najarian J . Cytomegalovirus-induced immune suppression. I. Humoral immunity. Clin Exp Immunol. 1974; 18(1):109-18. PMC: 1537980. View

10.

Howard R, Miller J, Najarian J . Cytomegalovirus-induced immune suppression. II. Cell-mediated immunity. Clin Exp Immunol. 1974; 18(1):119-26. PMC: 1537982. View

11.

Kauffman C, Linnemann Jr C, Schiff G, Phair J . Effect of viral and bacterial pneumonias on cell-mediated immunity in humans. Infect Immun. 1976; 13(1):78-83. PMC: 420579. DOI: 10.1128/iai.13.1.78-83.1976. View

12.

Glezen W, Fernald G . Effect of passive antibody on parainfluenza virus type 3 pneumonia in hamsters. Infect Immun. 1976; 14(1):212-6. PMC: 420865. DOI: 10.1128/iai.14.1.212-216.1976. View

13.

Jensen R, Pierson R, Braddy P, Saari D, Lauerman L, England J . Shipping fever pneumonia in yearling feedlot cattle. J Am Vet Med Assoc. 1976; 169(5):500-6. View

14.

Lopez A, Thomson R, Savan M . The pulmonary clearance of Pasteurella hemolytica in calves infected with bovine parainfluenza-3 virus. Can J Comp Med. 1976; 40(4):385-91. PMC: 1277569. View

15.

Chiorazzi N, Fox D, Katz D . Hapten-specific IgE antibody responses in mice. VI. Selective enhancement of IgE antibody production by low doses of X-irradiation and by cyclophosphamide. J Immunol. 1976; 117(5 Pt 1):1629-37. View

16.

Friend S, Wilkie B, Thomson R, Barnum D . Bovine pneumonic pasteurellosis: experimental induction in vaccinated and nonvaccinated calves. Can J Comp Med. 1977; 41(1):77-83. PMC: 1277695. View

17.

Friend S, Thomson R, Wilkie B . Pulmonary lesions induced by Pasteurella hemolytica in cattle. Can J Comp Med. 1977; 41(2):219-23. PMC: 1277724. View

18.

Hellum K . Standardization of the nitroblue tetrazolium test. Influence of pH, dye concentration and sample storage. Scand J Infect Dis. 1977; 9(2):125-30. DOI: 10.3109/inf.1977.9.issue-2.12. View

19.

Jericho K, Langford E . Pneumonia in calves produced with aerosols of bovine herpesvirus 1 and Pasteurella haemolytica. Can J Comp Med. 1978; 42(3):269-77. PMC: 1277638. View

20.

Jericho K . Update on pasteurellosis in young cattle. Can Vet J. 1979; 20(11):333-5. PMC: 1789631. View