Defective in Vitro Antibody Production to Varicella Zoster and Other Virus Antigens in Patients with Hodgkin's Disease

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1983 Aug 1

PMID 6309443

Citations 8

Authors

R L Souhami

J Babbage

A Sigfusson

Affiliations

Soon will be listed here.

Abstract

Cultures of blood mononuclear cells stimulated with Varicella zoster antigen (VZA) produced specific anti-VZA antibody in 20 of 27 normal adults but only 10 of 47 patients with treated Hodgkin's disease. Serum anti-VZA antibody levels were the same in normals and patients. The deficiency of in vitro production was found in patients who had been off treatment for 6 or more years and was not related to splenectomy. Each of 11 untreated patients had absent in vitro production from blood cells but spleen cultures produced antibody readily. Using combinations of autologous spleen and blood cells, the defect was attributable to the blood B cells. Defective production was also found in response to influenza viruses and herpes simplex. We suggest that an abnormality in B cell circulation with localization of antibody producing B cells in spleen and lymph nodes, is a feature of treated and untreated Hodgkin's disease.

Citing Articles

Antibody-dependent cell-mediated cytotoxicity to Varicella zoster.

Babbage J, Sigfusson A, Souhami R Clin Exp Immunol. 1984; 58(1):217-22.

PMID: 6090042 PMC: 1576969.

Defective in vitro antibody production in response to pokeweed mitogen and influenza antigen in patients with Hodgkin's disease.

Sigfusson A, Babbage J, Souhami R Clin Exp Immunol. 1985; 60(2):396-402.

PMID: 4006304 PMC: 1577021.

In vitro response to influenza immunisation by peripheral blood mononuclear cells from patients with systemic lupus erythematosus and other autoimmune diseases.

Turner-Stokes L, Cambridge G, Corcoran T, Oxford J, Snaith M Ann Rheum Dis. 1988; 47(7):532-5.

PMID: 3261154 PMC: 1003565. DOI: 10.1136/ard.47.7.532.

Immunisation of patients with rheumatoid arthritis and systemic lupus erythematosus.

Turner-Stokes L, Isenberg D Ann Rheum Dis. 1988; 47(7):529-31.

PMID: 3041923 PMC: 1003564. DOI: 10.1136/ard.47.7.529.

Varicella-zoster virus as a live vector for the expression of foreign genes.

Lowe R, Keller P, Keech B, Davison A, Whang Y, Morgan A Proc Natl Acad Sci U S A. 1987; 84(11):3896-900.

PMID: 3035557 PMC: 304983. DOI: 10.1073/pnas.84.11.3896.

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