Ca2+ Channel Modulation by 8-bromocyclic AMP in Cultured Heart Cells

Overview

Journal Nature

Specialty Science

Date 1983 Aug 4

PMID 6308462

Citations 97

Authors

A B Cachelin

J E de Peyer

S Kokubun

H Reuter

Affiliations

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Abstract

Modulation of ion channels is of increasing interest as it is an important step in the regulation of cellular functions. We have analysed the effect of 8-bromocyclic AMP on Ca2+ channels in cultured cardiac cells by the patch-clamp method and report here that there was a large increase in the probability of opening of the channels. On the basis of a recently proposed kinetic reaction scheme we suggest that cyclic AMP-dependent phosphorylation of Ca2+ channels primarily promotes the forward rate constants which lead to the open state of a Ca2+ channel during depolarization.

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