An Electrophysiological Study of Excitatory Neuromuscular Transmission in the Guinea-pig Main Pulmonary Artery

Overview

Journal J Physiol

Specialty Physiology

Date 1983 Mar 1

PMID 6308229

Citations 12

Authors

H Suzuki

Affiliations

Soon will be listed here.

Abstract

Electrical responses of single smooth muscle cells to perivascular nerve stimulation were recorded in the guinea-pig main pulmonary artery with a micro-electrode, to investigate neuromuscular transmission mechanisms. Perivascular nerve stimulation produced excitatory junction potentials in the smooth muscle cells of the main pulmonary artery. When stimulation was repetitive and of high frequency, a spike was seen in the early part of these potentials. Phentolamine, prazosin, phenoxybenzamine, guanethidine or tetrodotoxin all suppressed first the spike and then the junction potential. Exogenously applied noradrenaline also produced depolarization, and in high concentrations above 10(-6) M, spikes. Phentolamine again suppressed the spikes and then the depolarization. The results suggest that endogenous and exogenous noradrenaline act on the same type of receptor in this artery.

Citing Articles

An electrophysiological study of excitatory purinergic neuromuscular transmission in longitudinal smooth muscle of chicken anterior mesenteric artery.

Khalifa M, El-Mahmoudy A, Shiina T, Shimizu Y, Nikami H, El-Sayed M Br J Pharmacol. 2005; 144(6):830-9.

PMID: 15685211 PMC: 1576065. DOI: 10.1038/sj.bjp.0706076.

Direct and indirect effects of histamine on the smooth muscle cells of the guinea-pig main pulmonary artery.

Suzuki H, Kou K Pflugers Arch. 1983; 399(1):46-53.

PMID: 6647000 DOI: 10.1007/BF00652521.

Effects of alpha-adrenoceptor antagonists on electrical and mechanical responses of the isolated dog mesenteric vein to perivascular nerve stimulation and exogenous noradrenaline.

Kou K, Ibengwe J, Suzuki H Naunyn Schmiedebergs Arch Pharmacol. 1984; 326(1):7-13.

PMID: 6147761 DOI: 10.1007/BF00518772.

Adrenergic transmission in the dog mesenteric vein and its modulation by alpha-adrenoceptor antagonists.

Suzuki H Br J Pharmacol. 1984; 81(3):479-89.

PMID: 6141830 PMC: 1986859. DOI: 10.1111/j.1476-5381.1984.tb10101.x.

Roles of extrajunctional receptors in the response of guinea-pig mesenteric and rat tail arteries to adrenergic nerves.

Itoh T, Kitamura K, Kuriyama H J Physiol. 1983; 345:409-22.

PMID: 6141288 PMC: 1193804. DOI: 10.1113/jphysiol.1983.sp014985.

References

Speden R . Adrenergic transmission in small arteries. Nature. 1967; 216(5112):289-90. DOI: 10.1038/216289a0. View

Bell C . Transmission from vasoconstrictor and vasodilator nerves to single smooth muscle cells of the guinea-pig uterine artery. J Physiol. 1969; 205(3):695-708. PMC: 1348577. DOI: 10.1113/jphysiol.1969.sp008991. View

Graham J, Keatinge W . Differences in sensitivity to vasoconstrictor drugs within the wall of the sheep carotid artery. J Physiol. 1972; 221(2):477-92. PMC: 1331345. DOI: 10.1113/jphysiol.1972.sp009763. View

BEVAN J, Su C . Sympathetic mechanisms in blood vessels: nerve and muscle relationships. Annu Rev Pharmacol. 1973; 13:269-85. DOI: 10.1146/annurev.pa.13.040173.001413. View

Flower R . Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev. 1974; 26(1):33-67. View

Hirst G, Silinsky E . Some effects of 5-hydroxytryptamine, dopamine and noradrenaline on neurones in the submucous plexus of guinea-pig small intestine. J Physiol. 1975; 251(3):817-32. PMC: 1348419. DOI: 10.1113/jphysiol.1975.sp011124. View

Keatinge W, Torrie C . Action of sympathetic nerves of inner and outer muscle of sheep carotid artery, and effect of pressure on nerve distribution. J Physiol. 1976; 257(3):699-712. PMC: 1309387. DOI: 10.1113/jphysiol.1976.sp011393. View

McGrath M, SHEPHERD J . Inhibition of adrenergic neurotransmission in canine vascular smooth muscle by histamine: mediation by H2-receptors. Circ Res. 1976; 39(4):566-73. DOI: 10.1161/01.res.39.4.566. View

Kitamura K, Suzuki H, Kuriyama H . Prostaglandin action on the main pulmonary artery and portal vein of the rabbit. Jpn J Physiol. 1976; 26(6):681-92. DOI: 10.2170/jjphysiol.26.681. View

10.

Hedqvist P . Basic mechanisms of prostaglandin action on autonomic neurotransmission. Annu Rev Pharmacol Toxicol. 1977; 17:259-79. DOI: 10.1146/annurev.pa.17.040177.001355. View

11.

Westfall T . Local regulation of adrenergic neurotransmission. Physiol Rev. 1977; 57(4):659-728. DOI: 10.1152/physrev.1977.57.4.659. View

12.

Casteels R, Kitamura K, Kuriyama H, Suzuki H . The membrane properties of the smooth muscle cells of the rabbit main pulmonary artery. J Physiol. 1977; 271(1):41-61. PMC: 1353606. DOI: 10.1113/jphysiol.1977.sp011989. View

13.

Hirst G . Neuromuscular transmission in arterioles of guinea-pig submucosa. J Physiol. 1977; 273(1):263-75. PMC: 1353738. DOI: 10.1113/jphysiol.1977.sp012093. View

14.

Hirst G, Neild T . An analysis of excitatory junctional potentials recorded from arterioles. J Physiol. 1978; 280:87-104. PMC: 1282649. DOI: 10.1113/jphysiol.1978.sp012374. View

15.

Starke K, Weitzell R . Is histamine involved in the sympathomimetic effect of nicotine?. Naunyn Schmiedebergs Arch Pharmacol. 1978; 304(3):237-48. DOI: 10.1007/BF00507964. View

16.

Powell J . Effects of histamine on vascular sympathetic neuroeffector transmission. J Pharmacol Exp Ther. 1979; 208(3):360-5. View

17.

Holman M, Surprenant A . Some properties of the excitatory junction potentials recorded from saphenous arteries of rabbits. J Physiol. 1979; 287:337-51. PMC: 1281499. DOI: 10.1113/jphysiol.1979.sp012663. View

18.

Hirst G, Neild T . Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle. Nature. 1980; 283(5749):767-8. DOI: 10.1038/283767a0. View

19.

Hara Y, Kitamura K, Kuriyama H . Actions of 4-aminopyridine on vascular smooth muscle tissues of the guinea-pig. Br J Pharmacol. 1980; 68(1):99-106. PMC: 2044094. DOI: 10.1111/j.1476-5381.1980.tb10704.x. View

20.

Haeusler G, Thorens S . Effects of tetraethylammonium chloride on contractile, membrane and cable properties of rabbit artery muscle. J Physiol. 1980; 303:203-24. PMC: 1282887. DOI: 10.1113/jphysiol.1980.sp013281. View