Sequence of the C. Elegans Transposable Element Tc1

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1983 Jun 25

PMID 6306578

Citations 85

Authors

B Rosenzweig

L W Liao

D Hirsh

Affiliations

Soon will be listed here.

Abstract

The complete nucleotide sequence was determined for Tc1, a transposable element in the nematode Caenorhabditis elegans. The 1610-base-pair element terminates in 54-base-pair perfect inverted repeats and is flanked by a 2-base-pair duplication of the target sequence. The Tc1 sequence contains two long open reading frames on the same DNA strand but in different translational reading frames. The positions of transcriptional control sequences suggest that a single transcript is made, which could produce two polypeptides, 273 and 112 amino acids in length. These features, i.e. terminal repeats, target site duplication and open reading frames, make Tc1 similar to transposable elements from other species.

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References

KLENOW H, Henningsen I . Selective elimination of the exonuclease activity of the deoxyribonucleic acid polymerase from Escherichia coli B by limited proteolysis. Proc Natl Acad Sci U S A. 1970; 65(1):168-75. PMC: 286206. DOI: 10.1073/pnas.65.1.168. View

Brenner S . The genetics of Caenorhabditis elegans. Genetics. 1974; 77(1):71-94. PMC: 1213120. DOI: 10.1093/genetics/77.1.71. View

Sulston J, Brenner S . The DNA of Caenorhabditis elegans. Genetics. 1974; 77(1):95-104. PMC: 1213121. DOI: 10.1093/genetics/77.1.95. View

Proudfoot N, Brownlee G . 3' non-coding region sequences in eukaryotic messenger RNA. Nature. 1976; 263(5574):211-4. DOI: 10.1038/263211a0. View

Kindle K, Firtel R . Identification and analysis of Dictyostelium actin genes, a family of moderately repeated genes. Cell. 1978; 15(3):763-78. DOI: 10.1016/0092-8674(78)90262-3. View

Breathnach R, Benoist C, OHare K, Gannon F, Chambon P . Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries. Proc Natl Acad Sci U S A. 1978; 75(10):4853-7. PMC: 336219. DOI: 10.1073/pnas.75.10.4853. View

Emmons S, Klass M, Hirsh D . Analysis of the constancy of DNA sequences during development and evolution of the nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A. 1979; 76(3):1333-7. PMC: 383245. DOI: 10.1073/pnas.76.3.1333. View

Gannon F, OHare K, Perrin F, LePennec J, Benoist C, Cochet M . Organisation and sequences at the 5' end of a cloned complete ovalbumin gene. Nature. 1979; 278(5703):428-34. DOI: 10.1038/278428a0. View

Cameron J, Loh E, Davis R . Evidence for transposition of dispersed repetitive DNA families in yeast. Cell. 1979; 16(4):739-51. DOI: 10.1016/0092-8674(79)90090-4. View

10.

Benoist C, OHare K, Breathnach R, Chambon P . The ovalbumin gene-sequence of putative control regions. Nucleic Acids Res. 1980; 8(1):127-42. PMC: 327247. DOI: 10.1093/nar/8.1.127. View

11.

Tu C, Cohen S . Translocation specificity of the Tn3 element: characterization of sites of multiple insertions. Cell. 1980; 19(1):151-60. DOI: 10.1016/0092-8674(80)90396-7. View

12.

Rosenberg M, Court D . Regulatory sequences involved in the promotion and termination of RNA transcription. Annu Rev Genet. 1979; 13:319-53. DOI: 10.1146/annurev.ge.13.120179.001535. View

13.

Maxam A, Gilbert W . Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 1980; 65(1):499-560. DOI: 10.1016/s0076-6879(80)65059-9. View

14.

Farabaugh P, Fink G . Insertion of the eukaryotic transposable element Ty1 creates a 5-base pair duplication. Nature. 1980; 286(5771):352-6. DOI: 10.1038/286352a0. View

15.

Gafner J, Philippsen P . The yeast transposon Ty1 generates duplications of target DNA on insertion. Nature. 1980; 286(5771):414-8. DOI: 10.1038/286414a0. View

16.

Dunsmuir P, Brorein Jr W, Simon M, Rubin G . Insertion of the Drosophila transposable element copia generates a 5 base pair duplication. Cell. 1980; 21(2):575-9. DOI: 10.1016/0092-8674(80)90495-x. View

17.

Levis R, Dunsmuir P, Rubin G . Terminal repeats of the Drosophila transposable element copia: nucleotide sequence and genomic organization. Cell. 1980; 21(2):581-8. DOI: 10.1016/0092-8674(80)90496-1. View

18.

Potter S, Truett M, Phillips M, Maher A . Eucaryotic transposable genetic elements with inverted terminal repeats. Cell. 1980; 20(3):639-47. DOI: 10.1016/0092-8674(80)90310-4. View

19.

Smith D, Calvo J . Nucleotide sequence of the E coli gene coding for dihydrofolate reductase. Nucleic Acids Res. 1980; 8(10):2255-74. PMC: 324076. DOI: 10.1093/nar/8.10.2255. View

20.

Efstratiadis A, Posakony J, Maniatis T, Lawn R, OConnell C, Spritz R . The structure and evolution of the human beta-globin gene family. Cell. 1980; 21(3):653-68. DOI: 10.1016/0092-8674(80)90429-8. View