Mouse Mammary Tumour Virus Related Sequences Are Present in Human DNA

Overview

Journal Nucleic Acids Res

Publisher Oxford University Press

Specialty Biochemistry

Date 1983 Jun 25

PMID 6306576

Citations 16

Authors

F E May

B R Westley

H ROCHEFORT

E Buetti

H DIGGELMANN

Affiliations

Soon will be listed here.

Abstract

MuMTV-related sequences have been identified in the DNA of human breast cancer cells using the Southern transfer technique and hybridisation with cloned MuMTV DNA under conditions in which partially mismatched sequences form stable hybrids. Hybridisation with cloned fragments of the MuMTV genome showed that the gag-pol region shares the most homology (estimated to be greater than 80%) with the human MuMTV-related sequences, however, DNA fragments partially homologous to the MuMTV LTR, gag ad env regions were also detected. Analysis of several human DNA samples suggests that the majority of the human MuMTV-related sequences are genetically transmitted but additional Eco R1 fragments were detected in the DNA of one out of three breast cancer cell lines, MCF7. These sequences are potential probes for the human MuMTV-related retroviral sequences and will allow their possible role in human breast cancer to be evaluated.

Citing Articles

The Role of Oncogenic Viruses in the Pathogenesis of Sporadic Breast Cancer: A Comprehensive Review of the Current Literature.

Rossi C, Inzani F, Cesari S, Rizzo G, Paulli M, Pedrazzoli P Pathogens. 2024; 13(6).

PMID: 38921749 PMC: 11206847. DOI: 10.3390/pathogens13060451.

Prevalence and characteristics of mouse mammary tumor virus-like virus associated breast cancer in China.

Wang F, Zhang X, Yang M, Lin J, Yue Y, Li Y Infect Agent Cancer. 2021; 16(1):47.

PMID: 34174934 PMC: 8235620. DOI: 10.1186/s13027-021-00383-2.

Oncogenic Viruses and Breast Cancer: Mouse Mammary Tumor Virus (MMTV), Bovine Leukemia Virus (BLV), Human Papilloma Virus (HPV), and Epstein-Barr Virus (EBV).

Lawson J, Salmons B, Glenn W Front Oncol. 2018; 8:1.

PMID: 29404275 PMC: 5786831. DOI: 10.3389/fonc.2018.00001.

Mouse mammary tumor virus-like virus infection and the risk of human breast cancer: a meta-analysis.

Wang F, Hou J, Shen Q, Yue Y, Xie F, Wang X Am J Transl Res. 2014; 6(3):248-66.

PMID: 24936218 PMC: 4058307.

Characterization of novel reverse transcriptase encoding human endogenous retroviral sequences similar to type A and type B retroviruses: differential transcription in normal human tissues.

Medstrand P, Blomberg J J Virol. 1993; 67(11):6778-87.

PMID: 7692084 PMC: 238119. DOI: 10.1128/JVI.67.11.6778-6787.1993.

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