Partial Myeloperoxidase Deficiency in Preleukemia

Overview

Journal Blut

Specialty Hematology

Date 1983 Jul 1

PMID 6305446

Citations 2

Authors

P cech

M Markert

L H Perrin

Affiliations

Soon will be listed here.

Abstract

In seven subjects with partial and apparently acquired form of myeloperoxidase (MPO) deficiency, some functional properties of neutrophils (PMNs) were studied. Five patients suffered from preleukemia, one from diabetes mellitus and one from carcinoma of the breast with bone marrow metastases. Intracellular bactericidal activity, oxygen consumption and superoxide radical production were within normal limits. In three patients with preleukemia, the serum opsonic activity was markedly reduced (less than m-3SD) in an autologous system, but normal in the presence of pooled normal serum. Decreased opsonic activity was also found when these patient's sera were assayed in the presence of normal PMNs. Since the levels of IgG and C3 were comparable in the patients' sera and the pooled serum, a deficiency of another unknown opsonin or the presence of an opsonization inhibitor has to be postulated. The partial MPO defect apparently doesn't decrease the intracellular killing of Staphylococcus aureus by PMNs. The known susceptibility to bacterial infections in preleukemia may be explained by the reduction of serum opsonization conducing to a secondary decrease of the ingestion and killing of bacteria by the PMNs.

Citing Articles

Myeloperoxidase: a front-line defender against phagocytosed microorganisms.

Klebanoff S, Kettle A, Rosen H, Winterbourn C, Nauseef W J Leukoc Biol. 2012; 93(2):185-98.

PMID: 23066164 PMC: 3545676. DOI: 10.1189/jlb.0712349.

Superoxide anion production and expression of cytochrome b 558 by neutrophils are impaired in some patients with myelodysplastic syndrome.

Itoh Y, Kuratsuji T, Aizawa S, Sai M, Ohyashiki K, Toyama K Ann Hematol. 1991; 63(5):270-5.

PMID: 1659916 DOI: 10.1007/BF01698377.

References

Kitahara M, Eyre H, Simonian Y, Atkin C, Hasstedt S . Hereditary myeloperoxidase deficiency. Blood. 1981; 57(5):888-93. View

Dreyfus B . Preleukemic states. I. Definition and classification. II. Refractory anemia with an excess of myeloblasts in the bone marrow (smoldering acute leukemia). Nouv Rev Fr Hematol Blood Cells. 1976; 17(1-2):33-55. View

BRETON-GORIUS J, Coquin Y, Vilde J, Dreyfus B . Cytochemical and ultrastructural studies of aberrant granules in the neutrophils of two patients with myeloperoxidase deficiency during a preleukemic state: relationship to abnormal bactericidal activity. Nouv Rev Fr Hematol Blood Cells. 1976; 17(1-2):187-209. DOI: 10.1007/978-3-642-66312-3_13. View

Ruutu P, Ruutu T, VUOPIO P, Kosunen T, de la Chapelle A . Function of neutrophils in preleukaemia. Scand J Haematol. 1977; 18(4):317-25. DOI: 10.1111/j.1600-0609.1977.tb01202.x. View

cech P, Schneider P, Bachmann F . Partial myeloperoxidase deficiency. Acta Haematol. 1982; 67(3):180-4. DOI: 10.1159/000207052. View

Hunh D, Belohradsky B, Haas R . [Familial peroxidase-deficiency and acute myeloic leukemia (author's transl)]. Acta Haematol. 1978; 59(3):129-43. DOI: 10.1159/000207756. View

Dri P, Cramer R, Soranzo M, Comin A, Miotti V, Patriarca P . New approaches to the detection of myeloperoxidase deficiency. Blood. 1982; 60(2):323-7. View

Perrin L, Lambert P, MIESCHER P . Complement breakdown products in plasma from patients with systemic lupus erythematosus and patients with membranoproliferative or other glomerulonephritis. J Clin Invest. 1975; 56(1):165-76. PMC: 436567. DOI: 10.1172/JCI108065. View

Lehrer R, Cline M . Leukocyte myeloperoxidase deficiency and disseminated candidiasis: the role of myeloperoxidase in resistance to Candida infection. J Clin Invest. 1969; 48(8):1478-88. PMC: 322375. DOI: 10.1172/JCI106114. View

10.

Nessi P, Frei J . Leucocyte energy metabolism. VI. Simultaneous and improved isolation of lymphocytes and polymorphonuclear leucocytes from a single of human blood. Enzyme. 1977; 22(3):176-82. View

11.

Kitahara M, Kushner J . Acquired myeloperoxidase deficiency and recurrent infections in a patient with acute myelomonocytic leukemia. Cancer. 1979; 44(6):2244-8. DOI: 10.1002/1097-0142(197912)44:6<2244::aid-cncr2820440636>3.0.co;2-g. View

12.

cech P, Papathanassiou A, Boreux G, Roth P, MIESCHER P . Hereditary myeloperoxidase deficiency. Blood. 1979; 53(3):403-11. View

13.

Cramer R, Soranzo M, Dri P, ROTTINI G, Bramezza M, CIRIELLI S . Incidence of myeloperoxidase deficiency in an area of northern Italy: histochemical, biochemical and functional studies. Br J Haematol. 1982; 51(1):81-7. DOI: 10.1111/j.1365-2141.1982.tb07292.x. View

14.

Marker M, Frei J . The energy metabolism of the leucocyte. X. Kinetics of oxygen consumption during phagocytosis by polymorphonuclear leucocytes. A photometric method. Enzyme. 1979; 24(5):327-36. DOI: 10.1159/000458683. View

15.

Catovsky D, Shaw M, Hoffbrand A, Dacie J . Sideroblastic anaemia and its association with leukaemia and myelomatosis: a report of five cases. Br J Haematol. 1971; 20(4):385-93. DOI: 10.1111/j.1365-2141.1971.tb07050.x. View

16.

Nydegger U, Achermann L, Lambert P, MIESCHER P . A simple automated method for complement estimation in a continuous flow system. J Immunol. 1972; 109(4):910-3. View

17.

Tan J, Watanakunakorn C, Phair J . A modified assay of neutrophil function: use of lysostaphin to differentiate defective phagocytosis from impaired intracellular killing. J Lab Clin Med. 1971; 78(2):316-22. View

18.

Fletcher J . Impaired neutrophil function and myeloperoxidase deficiency in pregnancy. Br J Haematol. 1980; 44(3):375-81. DOI: 10.1111/j.1365-2141.1980.tb05906.x. View

19.

Lehrer R, Goldberg L, APPLE M, Rosenthal N . Refractory megaloblastic anemia with myeloperoxidase-deficient neutrophils. Ann Intern Med. 1972; 76(3):447-53. DOI: 10.7326/0003-4819-76-3-447. View

20.

Proctor R, Prendergast E, Mosher D . Fibronectin mediates attachment of Staphylococcus aureus to human neutrophils. Blood. 1982; 59(4):681-7. View