Latency of Herpes Simplex Virus in Ocular Tissue of Mice

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1983 Feb 1

PMID 6299954

Citations 11

Authors

H Openshaw

Affiliations

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Abstract

At 5 to 7 months after corneal inoculation of herpes simplex virus type 1 in mice, explants of ocular tissue yielded virus. Immunoperoxidase study of explants undergoing reactivation revealed herpes simplex virus antigens in retinal tissue. These results indicate that herpes simplex virus can establish and maintain latency in ocular tissue, most probably in the retina.

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Ocular herpes simplex virus: how are latency, reactivation, recurrent disease and therapy interrelated?.

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Slow viral replication of HSV-1 is responsible for early recurrence of herpetic keratitis after corneal grafting.

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Recurrent herpes labialis as a potential risk factor for nonarteritic anterior ischemic optic neuropathy.

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