» Articles » PMID: 6299778

Influence of Chronic UV-light Exposure on Hepatic and Cutaneous Monooxygenases

Overview
Journal Experientia
Specialty Science
Date 1983 Apr 15
PMID 6299778
Citations 6
Authors
Affiliations
Soon will be listed here.
Abstract

Hairless female Ng/-mice were irradiated by UV-light for 16 h daily over a period of 24 weeks. Monooxygenase activities were measured in liver and skin, and an induction of the aryl-hydrocarbon hydroxylase was detected in liver by both fluorometric and radiochemical methods, whereas no induction of this enzyme could be demonstrated in the skin.

Citing Articles

Endocrine aryl hydrocarbon receptor signaling is induced by moderate cutaneous exposure to ultraviolet light.

Memari B, Nguyen-Yamamoto L, Salehi-Tabar R, Zago M, Fritz J, Baglole C Sci Rep. 2019; 9(1):8486.

PMID: 31186463 PMC: 6560103. DOI: 10.1038/s41598-019-44862-4.


Ligand activation of the Ah receptor contributes to gastrointestinal homeostasis.

Murray I, Perdew G Curr Opin Toxicol. 2017; 2:15-23.

PMID: 28944314 PMC: 5604257. DOI: 10.1016/j.cotox.2017.01.003.


25-Hydroxyvitamin D and its C-3 epimer are elevated in the skin and serum of Skh-1 mice supplemented with dietary vitamin D.

Teegarden M, Campbell A, Cooperstone J, Tober K, Schwartz S, Oberyszyn T Mol Nutr Food Res. 2017; 61(10).

PMID: 28589636 PMC: 5629121. DOI: 10.1002/mnfr.201700293.


The search for endogenous activators of the aryl hydrocarbon receptor.

Nguyen L, Bradfield C Chem Res Toxicol. 2007; 21(1):102-16.

PMID: 18076143 PMC: 2572005. DOI: 10.1021/tx7001965.


Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation.

Fritsche E, Schafer C, Calles C, Bernsmann T, Bernshausen T, Wurm M Proc Natl Acad Sci U S A. 2007; 104(21):8851-6.

PMID: 17502624 PMC: 1885591. DOI: 10.1073/pnas.0701764104.


References
1.
Paine A . Induction of benzo[a]pyrene Mono-oxygenase in liver cell culture by the photochemical generation of active oxygen species. Evidence for the involvement of singlet oxygen and the formation of a stable inducing intermediate. Biochem J. 1976; 158(1):109-17. PMC: 1163943. DOI: 10.1042/bj1580109. View

2.
Goerz G, Vizethum W, Tsambaos D . Cutaneous cytochrome P-450 activity during hexachlorobenzene-induced experimental porphyria in rats. Arch Dermatol Res. 1979; 265(1):111-4. DOI: 10.1007/BF00412708. View

3.
Van Cantfort J, De Graeve J, Gielen J . Radioactive assay for aryl hydrocarbon hydroxylase. Improved method and biological importance. Biochem Biophys Res Commun. 1977; 79(2):505-12. DOI: 10.1016/0006-291x(77)90186-3. View

4.
Chan J, Black H . Skin carcinogenesis: cholesterol-5alpha,6alpha-epoxide hydrase activity in mouse skin irradiated with ultraviolet light. Science. 1974; 186(4170):1216-7. DOI: 10.1126/science.186.4170.1216. View

5.
Omura T, Sato R . THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. I. EVIDENCE FOR ITS HEMOPROTEIN NATURE. J Biol Chem. 1964; 239:2370-8. View