Cell-mediated Immunity in Mice with Primary, Secondary and Latent Herpes Simplex Virus Infection

Overview

Journal Arch Virol

Specialty Microbiology

Date 1982 Jan 1

PMID 6299234

Authors

J M Darville

W A Blyth

Affiliations

Soon will be listed here.

Abstract

Cell mediated immunity was studied by a cytopathic effect inhibition assay in mice infected in the ear with herpes simplex virus type 1 (HSV 1). Activity appeared rapidly, reaching a high level 6 days after primary infection. It had fallen 10 days after infection and was undetectable during latency, 3-5 weeks after infection. The activity reappeared even more rapidly and strongly after reinoculation with the virus, but stimuli designed to induce recurrent disease did not induce clinical disease in the animals and no activity was detected in them. The activity, which was specific for HSV, was shown to be mediated by T-lymphocytes.

References

FIELD H, Darby G . Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo. Antimicrob Agents Chemother. 1980; 17(2):209-16. PMC: 283760. DOI: 10.1128/AAC.17.2.209. View

Muller S, HERRMANN Jr E, Winkelmann R . Herpes simplex infections in hematologic malignancies. Am J Med. 1972; 52(1):102-14. DOI: 10.1016/0002-9343(72)90012-5. View

Nash A, Quartey-Papafio R, Wildy P . Cell-mediated immunity in herpes simplex virus-infected mice: functional analysis of lymph node cells during periods of acute and latent infection, with reference to cytotoxic and memory cells. J Gen Virol. 1980; 49(2):309-17. DOI: 10.1099/0022-1317-49-2-309. View

Darville J, Blyth W . Neutralising antibody in mice with primary and recurrent herpes simplex virus infection. Arch Virol. 1982; 71(4):303-10. DOI: 10.1007/BF01315060. View

Simmons R, Centifanto Y, Kaufman H . Plaque size reduction as a measure of viral cell-mediated immunity. Infect Immun. 1974; 10(5):1034-9. PMC: 423057. DOI: 10.1128/iai.10.5.1034-1039.1974. View

Harbour D, Hill T, Blyth W . Acute and recurrent herpes simplex in several strains of mice. J Gen Virol. 1981; 55(Pt 1):31-40. DOI: 10.1099/0022-1317-55-1-31. View

Howes E, Taylor W, Mitchison N, Simpson E . MHC matching shows that at least two T-cell subsets determine resistance to HSV. Nature. 1979; 277(5691):66-8. DOI: 10.1038/277067a0. View

Sethi K, BRANDIS H . Specifically immune mouse T-cells can destroy H-2 compatible murine target cells infected with herpes simplex virus types 1 or 2. Z Immunitatsforsch Immunobiol. 1977; 153(2):162-73. View

Korsager B, SPENCER E, Mordhorst C, Andersen H . Herpesvirus hominis infections in renal transplant recipients. Scand J Infect Dis. 1975; 7(1):11-9. DOI: 10.3109/inf.1975.7.issue-1.03. View

10.

Underwood G, WEED S . Recurrent cutaneous herpes simplex in hairless mice. Infect Immun. 1974; 10(3):471-4. PMC: 422977. DOI: 10.1128/iai.10.3.471-474.1974. View

11.

Rouse B, Babiuk L . Host defense mechanisms against infectious bovine rhinotracheitis virus. II. Inhibition of viral plaque formation by immune peripheral blood lymphocytes. Cell Immunol. 1975; 17(1):43-56. DOI: 10.1016/s0008-8749(75)80005-0. View

12.

Ennis F . Host defense mechanisms against Herpes simplex virus. I. Control of infection in vitro by senstized spleen cells and antibody. Infect Immun. 1973; 7(6):898-904. PMC: 422780. DOI: 10.1128/iai.7.6.898-904.1973. View

13.

Rager-Zisman B, Allison A . Mechanism of immunologic resistance to herpes simplex virus 1 (HSV-1) infection. J Immunol. 1976; 116(1):35-40. View

14.

Pfizenmaier K, Jung H, Starzinski-Powitz A, Rollinghoff M, Wagner H . The role of T cells in anti-herpes simplex virus immunity. I. Induction of antigen-specific cytotoxic T lymphocytes. J Immunol. 1977; 119(3):939-44. View

15.

Blyth W, Harbour D, Hill T . Effect of immunosuppression on recurrent herpes simplex in mice. Infect Immun. 1980; 29(3):902-7. PMC: 551216. DOI: 10.1128/iai.29.3.902-907.1980. View

16.

Julius M, Simpson E, Herzenberg L . A rapid method for the isolation of functional thymus-derived murine lymphocytes. Eur J Immunol. 1973; 3(10):645-9. DOI: 10.1002/eji.1830031011. View

17.

Montgomerie J, BECROFT D, Croxson M, DOAK P, North J . Herpes-simplex-virus infection after renal transplantation. Lancet. 1969; 2(7626):867-71. DOI: 10.1016/s0140-6736(69)92327-7. View

18.

Nash A, FIELD H, Quartey-Papafio R . Cell-mediated immunity in herpes simplex virus-infected mice: induction, characterization and antiviral effects of delayed type hypersensitivity. J Gen Virol. 1980; 48(Pt 2):351-7. DOI: 10.1099/0022-1317-48-2-351. View

19.

Doherty P, Blanden R, Zinkernagel R . Specificity of virus-immune effector T cells for H-2K or H-2D compatible interactions: implications for H-antigen diversity. Transplant Rev. 1976; 29:89-124. DOI: 10.1111/j.1600-065x.1976.tb00198.x. View

20.

Armstrong J, Evans A, Rao N, Ho M . Viral infections in renal transplant recipients. Infect Immun. 1976; 14(4):970-5. PMC: 415480. DOI: 10.1128/iai.14.4.970-975.1976. View