Oz S, Keren-Raifman T, Sharon T, Subramaniam S, Pallien T, Katz M
BMC Biol. 2024; 22(1):276.
PMID: 39609812
PMC: 11603854.
DOI: 10.1186/s12915-024-02076-9.
Gary C, Acharige N, Oyewumi T, Pflum M
J Biol Chem. 2024; 300(8):107588.
PMID: 39032654
PMC: 11375270.
DOI: 10.1016/j.jbc.2024.107588.
Olivieri C, Wang Y, Walker C, Veliparambil Subrahmanian M, Ha K, Bernlohr D
Elife. 2024; 12.
PMID: 38913408
PMC: 11196109.
DOI: 10.7554/eLife.91506.
Bremer H, Herppich A, Pflum M
Bioorg Med Chem Lett. 2024; 109:129841.
PMID: 38838920
PMC: 11305616.
DOI: 10.1016/j.bmcl.2024.129841.
Tolone A, Haq W, Fachinger A, Roy A, Kesh S, Rentsch A
Int J Mol Sci. 2023; 24(20).
PMID: 37894958
PMC: 10607377.
DOI: 10.3390/ijms242015277.
Binding mechanism and biological effects of flavone DYRK1A inhibitors for the design of new antidiabetics.
Pustelny K, Grygier P, Barzowska A, Pucelik B, Matsuda A, Mrowiec K
Sci Rep. 2023; 13(1):18114.
PMID: 37872245
PMC: 10593742.
DOI: 10.1038/s41598-023-44810-3.
Affinity-Based Kinase-Catalyzed Crosslinking to Study Kinase-Substrate Pairs.
Beltman R, Herppich A, Bremer H, Pflum M
Bioconjug Chem. 2023; 34(6):1054-1060.
PMID: 37279085
PMC: 10648467.
DOI: 10.1021/acs.bioconjchem.3c00131.
On the Origins of Enzymes: Phosphate-Binding Polypeptides Mediate Phosphoryl Transfer to Synthesize Adenosine Triphosphate.
Vyas P, Malitsky S, Itkin M, Tawfik D
J Am Chem Soc. 2023; .
PMID: 36951643
PMC: 10119929.
DOI: 10.1021/jacs.2c08636.
Silmitasertib (CX-4945), a Clinically Used CK2-Kinase Inhibitor with Additional Effects on GSK3β and DYRK1A Kinases: A Structural Perspective.
Grygier P, Pustelny K, Nowak J, Golik P, Popowicz G, Plettenburg O
J Med Chem. 2023; 66(6):4009-4024.
PMID: 36883902
PMC: 10041529.
DOI: 10.1021/acs.jmedchem.2c01887.
A PKA inhibitor motif within SMOOTHENED controls Hedgehog signal transduction.
Happ J, Arveseth C, Bruystens J, Bertinetti D, Nelson I, Olivieri C
Nat Struct Mol Biol. 2022; 29(10):990-999.
PMID: 36202993
PMC: 9696579.
DOI: 10.1038/s41594-022-00838-z.
An auto-inhibited state of protein kinase G and implications for selective activation.
Sharma R, Kim J, Qin L, Henning P, Akimoto M, VanSchouwen B
Elife. 2022; 11.
PMID: 35929723
PMC: 9417419.
DOI: 10.7554/eLife.79530.
Crystal structure of the phosphorylated MKK5 reveals activation mechanism of MAPK kinases.
Pei C, He Q, Luo Z, Yao H, Wang Z, Wu J
Acta Biochim Biophys Sin (Shanghai). 2022; 54(8):1159-1170.
PMID: 35866601
PMC: 9909325.
DOI: 10.3724/abbs.2022089.
DYRK1A Kinase Inhibitors Promote β-Cell Survival and Insulin Homeostasis.
Barzowska A, Pucelik B, Pustelny K, Matsuda A, Martyniak A, Stepniewski J
Cells. 2021; 10(9).
PMID: 34571911
PMC: 8467532.
DOI: 10.3390/cells10092263.
Is Disrupted Nucleotide-Substrate Cooperativity a Common Trait for Cushing's Syndrome Driving Mutations of Protein Kinase A?.
Walker C, Wang Y, Olivieri C, V S M, Gao J, Bernlohr D
J Mol Biol. 2021; 433(18):167123.
PMID: 34224748
PMC: 8409435.
DOI: 10.1016/j.jmb.2021.167123.
Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A.
Olivieri C, Walker C, Karamafrooz A, Wang Y, Manu V, Porcelli F
Commun Biol. 2021; 4(1):321.
PMID: 33692454
PMC: 7946884.
DOI: 10.1038/s42003-021-01819-6.
Structural Characterization of Glycerol Kinase from the Thermophilic Fungus .
Wilk P, Kuska K, Wator E, Malecki P, Wos K, Tokarz P
Int J Mol Sci. 2020; 21(24).
PMID: 33339113
PMC: 7765489.
DOI: 10.3390/ijms21249570.
Intrinsically disordered linkers control tethered kinases via effective concentration.
Dyla M, Kjaergaard M
Proc Natl Acad Sci U S A. 2020; 117(35):21413-21419.
PMID: 32817491
PMC: 7474599.
DOI: 10.1073/pnas.2006382117.
Molecular Basis for Ser/Thr Specificity in PKA Signaling.
Knape M, Wallbott M, Burghardt N, Bertinetti D, Hornung J, Schmidt S
Cells. 2020; 9(6).
PMID: 32630525
PMC: 7361990.
DOI: 10.3390/cells9061548.
Mechanism of allosteric inhibition in the cGMP-dependent protein kinase.
Byun J, Van K, Huang J, Henning P, Franz E, Akimoto M
J Biol Chem. 2020; 295(25):8480-8491.
PMID: 32317283
PMC: 7307193.
DOI: 10.1074/jbc.RA120.013070.
Cushing's syndrome driver mutation disrupts protein kinase A allosteric network, altering both regulation and substrate specificity.
Walker C, Wang Y, Olivieri C, Karamafrooz A, Casby J, Bathon K
Sci Adv. 2019; 5(8):eaaw9298.
PMID: 31489371
PMC: 6713507.
DOI: 10.1126/sciadv.aaw9298.