The Roles of Individual Polyoma Virus Early Proteins in Oncogenic Transformation

Overview

Journal Nature

Specialty Science

Date 1982 Dec 23

PMID 6294529

Citations 133

Authors

M Rassoulzadegan

A Cowie

A Carr

N Glaichenhaus

R Kamen

F Cuzin

Affiliations

Soon will be listed here.

Abstract

The expression in normal rat cells of modified polyoma virus genomes, separately encoding large T, middle T or small T antigens, has allowed the investigation of the roles of these proteins in oncogenic transformation. Middle T is sufficient to transform cells of established lines but the transformants are serum dependent. Large T lacks intrinsic oncogenic potential but can relieve the serum dependence of normal and transformed cells. Middle T alone cannot transform primary rat embryo fibroblasts.

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