Pituitary Function Before and After Transsphenoidal Adenomectomy in Patients with Cushing's Disease

Overview

Journal Acta Neurochir (Wien)

Specialty Neurosurgery

Date 1982 Jan 1

PMID 6291339

Citations 3

Authors

B Ambrosi

M Giovanelli

S M Gaini

D Bochicchio

E Riva

G Tomei

M Zavanone

G Faglia

Affiliations

Soon will be listed here.

Abstract

Over the past 4 years 11 patients with Cushing's disease have been operated on by a transsphenoidal microsurgical technique. All patients had small intrahypophyseal adenomas found at operation. Eight of the 11 patients had a remission of the disease on the basis of clinical evaluation and hormonal studies. The endocrinological results revealed a transient state of hypocorticism in all successfully treated patients. Within 6-8 months after operation recovery of hypothalamic-pituitary-adrenal function and other tropin function took place. These findings, together with the absence of recurrence up to now, further confirm the efficacy of transsphenoidal surgery in the management of patients with Cushing's disease.

Citing Articles

Recovery of the hypothalamic-pituitary-adrenal axis in children and adolescents after surgical cure of Cushing's disease.

Lodish M, Dunn S, Sinaii N, Keil M, Stratakis C J Clin Endocrinol Metab. 2012; 97(5):1483-91.

PMID: 22399509 PMC: 3339895. DOI: 10.1210/jc.2011-2325.

Transsphenoidal surgery for Cushing's disease.

Fahlbusch R, Buchfelder M, Muller O J R Soc Med. 1986; 79(5):262-9.

PMID: 3014145 PMC: 1290309. DOI: 10.1177/014107688607900504.

Diagnosis, treatment and postoperative results of Cushing's disease.

Kageyama N, Kuwayama A, Takahashi T, Negoro M, Ichihara K Neurosurg Rev. 1985; 8(3-4):177-83.

PMID: 2993955 DOI: 10.1007/BF01815442.

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