Some Effects of Gamma-linolenic Acid on Cultured Human Oesophageal Carcinoma Cells

Overview

Journal S Afr Med J

Specialty General Medicine

Date 1982 Oct 30

PMID 6291175

Citations 5

Authors

W P Leary

K M Robinson

J Booyens

N Dippenaar

Affiliations

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Abstract

Cells of two continuous human oesophageal carcinoma lines were treated by the addition of gamma-linolenic acid (GLA) at concentrations of 10-60 micrograms/ml culture medium. After 7 days of exposure to GLA, pronounced morphological changes became evident and culminated in cell death. GLA-mediated effects were time- and dose-dependent and varied slightly with the degree of histological differentiation of the lines tested. These findings may have clinical implications.

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